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Submit ReviewPFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.
M. Wt | 293.4 |
Formula | C14H15NO2S2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1558598-41-6 |
PubChem ID | 2145809 |
InChI Key | GPURHDUTZUYAFI-GHXNOFRVSA-N |
Smiles | CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.34 | 100 | |
ethanol | 29.34 | 100 |
The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.41 mL | 17.04 mL | 34.08 mL |
5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
10 mM | 0.34 mL | 1.7 mL | 3.41 mL |
50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
References are publications that support the biological activity of the product.
Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220
If you know of a relevant reference for PFM 01, please let us know.
Keywords: PFM 01, PFM 01 supplier, PFM01, MRE11, meiotic, recombination, 11, homolog, A, endonuclease, inhibitors, inhibits, non-homologous, end-joining, NHEJ, HR, DNA,, RNA, and, Protein, Synthesis, 6222, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for PFM 01 include:
Benedikt M et al (2021) p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep 35 109153 PMID: 34038735
George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235
Do you know of a great paper that uses PFM 01 from Tocris? Please let us know.
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