PFM 01

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Cat.No. 6222 - PFM 01 | C14H15NO2S2 | CAS No. 1558598-41-6
Description: MRE11 endonuclease inhibitor
Chemical Name: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)

Biological Activity

MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

Technical Data

M. Wt 293.4
Formula C14H15NO2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1558598-41-6
PubChem ID 2145809
Smiles CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.34 100
ethanol 29.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220

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