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Biological Activity for PFM 01
PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.
Technical Data for PFM 01
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PFM 01
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PFM 01
The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.41 mL||17.04 mL||34.08 mL|
|5 mM||0.68 mL||3.41 mL||6.82 mL|
|10 mM||0.34 mL||1.7 mL||3.41 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References for PFM 01
References are publications that support the biological activity of the product.
Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220
If you know of a relevant reference for PFM 01, please let us know.
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Citations for PFM 01
Citations are publications that use Tocris products.
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Reviews for PFM 01
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Literature in this Area
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Cell Cycle and DNA Damage Research Product GuideNew
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