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PFM 01

Cat. No. 6222 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MRE11 endonuclease inhibitor
Chemical Name: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PFM 01

PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

Technical Data for PFM 01

M. Wt 293.4
Formula C14H15NO2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1558598-41-6
PubChem ID 2145809
InChI Key GPURHDUTZUYAFI-GHXNOFRVSA-N
Smiles CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PFM 01

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
ethanol 29.34 100

Preparing Stock Solutions for PFM 01

The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for PFM 01

References are publications that support the biological activity of the product.

Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220

If you know of a relevant reference for PFM 01, please let us know.

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Keywords: PFM 01, PFM 01 supplier, PFM01, MRE11, meiotic, recombination, 11, homolog, A, endonuclease, inhibitors, inhibits, non-homologous, end-joining, NHEJ, HR, DNA,, RNA, and, Protein, Synthesis, 6222, Tocris Bioscience

2 Citations for PFM 01

Citations are publications that use Tocris products. Selected citations for PFM 01 include:

Benedikt M et al (2021) p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep 35 109153 PMID: 34038735

George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235

Do you know of a great paper that uses PFM 01 from Tocris? Please let us know.

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Literature in this Area

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