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PFM 01

Cat. No. 6222 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

6222 has been discontinued.

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Description: MRE11 endonuclease inhibitor
Chemical Name: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for PFM 01

PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

Technical Data for PFM 01

M. Wt 293.4
Formula C14H15NO2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1558598-41-6
PubChem ID 2145809
InChI Key GPURHDUTZUYAFI-GHXNOFRVSA-N
Smiles CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PFM 01

References are publications that support the biological activity of the product.

Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220

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Keywords: PFM 01, PFM 01 supplier, PFM01, MRE11, meiotic, recombination, 11, homolog, A, endonuclease, inhibitors, inhibits, non-homologous, end-joining, NHEJ, HR, DNA,, RNA, and, Protein, Synthesis, 6222, Tocris Bioscience

2 Citations for PFM 01

Citations are publications that use Tocris products. Selected citations for PFM 01 include:

Benedikt M et al (2021) p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep 35 109153 PMID: 34038735

George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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