Discontinued Product

[(pF)Phe4]Nociceptin(1-13)NH2 (Cat. No. 1566) has been withdrawn from sale for commercial reasons.
Description: Potent, selective nociceptin receptor agonist
Literature (1)

Biological Activity for [(pF)Phe4]Nociceptin(1-13)NH2

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.

Technical Data for [(pF)Phe4]Nociceptin(1-13)NH2

M. Wt 1399.6
Formula C61H99FN22O15

(Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 380620-88-2
PubChem ID 10260917
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(F)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for [(pF)Phe4]Nociceptin(1-13)NH2

Certificate of Analysis / Product Datasheet
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References for [(pF)Phe4]Nociceptin(1-13)NH2

References are publications that support the biological activity of the product.

Bigoni et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 442 PMID: 12070757

Guerrini et al (2001) Structure-activity studies of the Phe4 residue of nociceptin(1-13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 44 3956 PMID: 11689082

Rizzi et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 450 PMID: 12070758

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Keywords: [(pF)Phe4]Nociceptin(1-13)NH2, [(pF)Phe4]Nociceptin(1-13)NH2 supplier, Potent, selective, nociceptin, receptor, agonists, Receptors, ORL1, OP4, NOP, Opioids, 1566, Tocris Bioscience

Citations for [(pF)Phe4]Nociceptin(1-13)NH2

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Currently there are no citations for [(pF)Phe4]Nociceptin(1-13)NH2.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.