Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.
(Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1399.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.71 mL||3.57 mL||7.14 mL|
|5 mM||0.14 mL||0.71 mL||1.43 mL|
|10 mM||0.07 mL||0.36 mL||0.71 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bigoni et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 442 PMID: 12070757
Guerrini et al (2001) Structure-activity studies of the Phe4 residue of nociceptin(1-13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 44 3956 PMID: 11689082
Rizzi et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 450 PMID: 12070758
If you know of a relevant reference for [(pF)Phe4]Nociceptin(1-13)NH2, please let us know.
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Keywords: [(pF)Phe4]Nociceptin(1-13)NH2, supplier, Potent, selective, nociceptin, receptor, agonists, Receptors, ORL1, OP4, NOP, Opioids, NOP, Receptors, Tocris Bioscience
Citations for [(pF)Phe4]Nociceptin(1-13)NH2
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