PF CBP1

Discontinued Product

PF CBP1 (Cat. No. 5801) has been withdrawn from sale for commercial reasons.
Cat.No. 5801 - PF CBP1 | C29H36N4O3 | CAS No. 1962928-21-7
Description: Selective CBP/p300 bromodomain inhibitor
Chemical Name: 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for PF CBP1

Selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively). Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro.

Negative Control also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Informaiton for PF CBP1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF CBP1 is reviewed on the chemical probes website.

Technical Data for PF CBP1

M. Wt 488.62
Formula C29H36N4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1962928-21-7
PubChem ID 119081417
InChI Key CGWBJJZOKGZCSJ-UHFFFAOYSA-N
Smiles CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCC)C=C3)N4CCN5CCOCC5)=C4C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PF CBP1

Certificate of Analysis / Product Datasheet
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References for PF CBP1

References are publications that support the biological activity of the product.

Chekler et al (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588 PMID: 26670081

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Keywords: PF CBP1, PF CBP1 supplier, PFCBP1, selective, CBP, CREBBP, EP300, bromodomains, inhibitors, inhibits, Bromodomains, 5801, Tocris Bioscience

Citations for PF CBP1

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Currently there are no citations for PF CBP1.

Reviews for PF CBP1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Epigenetics Research Bulletin

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