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Submit ReviewISOX INACT
Description: Negative control for PF-CBP1
Chemical Name: 5-(Dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]--4,6-dimethyl-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazole
Purity: ≥98% (HPLC)
Biological Activity
Negative control for PF CBP1. Exhibits negligible activity at CBP and BRD4.
Active Analog also available.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 488.62 |
| Formula | C29H36N4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 121237856 |
| InChI Key | FTOHXUPHICJSCR-UHFFFAOYSA-N |
| Smiles | CC(ON=C1C)=C1C2=C(C)C(N=C(CCC3=CC=C(OC)C=C3)N4CCN5CCOCC5)=C4C=C2C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.43 | 50 | |
| ethanol | 9.77 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 488.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.09 mL | 20.47 mL | 40.93 mL |
| 2.5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Chekler et al (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588 PMID: 26670081
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Citations for ISOX INACT
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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