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Biological Activity for PCNA I1
PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.
Technical Data for PCNA I1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PCNA I1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PCNA I1
The following data is based on the product molecular weight 310.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.22 mL||16.11 mL||32.22 mL|
|5 mM||0.64 mL||3.22 mL||6.44 mL|
|10 mM||0.32 mL||1.61 mL||3.22 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References for PCNA I1
References are publications that support the biological activity of the product.
Tan et al (2012) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol.Pharmacol. 81 811 PMID: 22399488
Dillehay et al (2014) Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol.Cancer Ther. 13 2817 PMID: 25253786
If you know of a relevant reference for PCNA I1, please let us know.
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Citations for PCNA I1
Citations are publications that use Tocris products.
Currently there are no citations for PCNA I1. Do you know of a great paper that uses PCNA I1 from Tocris? Please let us know.
Reviews for PCNA I1
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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