Pricing Availability   Qty
Cat.No. 5419 - PCNA I1 | C17H14N2O2S | CAS No. 444930-42-1
Description: PCNA inhibitor
Chemical Name: N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for PCNA I1

PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

Technical Data for PCNA I1

M. Wt 310.37
Formula C17H14N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 444930-42-1
PubChem ID 5410824
Smiles O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PCNA I1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.04 100

Preparing Stock Solutions for PCNA I1

The following data is based on the product molecular weight 310.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.11 mL 32.22 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for PCNA I1

References are publications that support the biological activity of the product.

Tan et al (2012) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol.Pharmacol. 81 811 PMID: 22399488

Dillehay et al (2014) Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol.Cancer Ther. 13 2817 PMID: 25253786

If you know of a relevant reference for PCNA I1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: PCNA I1, PCNA I1 supplier, PCNA11, Proliferating, cell, nuclear, antigen, PCNA, inhibits, inhibitors, anticancer, cycle, arrest, DNA,, RNA, and, Protein, Synthesis, 5419, Tocris Bioscience

Citations for PCNA I1

Citations are publications that use Tocris products.

Currently there are no citations for PCNA I1. Do you know of a great paper that uses PCNA I1 from Tocris? Please let us know.

Reviews for PCNA I1

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used PCNA I1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

PCNAI1 quickly kills melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

PCNA I1 was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis