PCNA I1

Pricing Availability Delivery Time Qty
Cat.No. 5419 - PCNA I1 | C17H14N2O2S | CAS No. 444930-42-1
Description: PCNA inhibitor
Chemical Name: N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

Technical Data

M. Wt 310.37
Formula C17H14N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 444930-42-1
PubChem ID 5410824
InChI Key WNYIQPCMVYAJLQ-JLHYYAGUSA-N
Smiles O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 310.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.11 mL 32.22 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tan et al (2012) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol.Pharmacol. 81 811 PMID: 22399488

Dillehay et al (2014) Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol.Cancer Ther. 13 2817 PMID: 25253786


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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis