Pam2CSK4 Biotin

Pricing Availability Delivery Time Qty
Cat.No. 4638 - Pam2CSK4 Biotin | Pam2-Cys-Ser-Lys-Lys-Lys-Lys-Aca-Aca-Biotin
Description: Biotinylated Pam2CSK4 (Cat. No. 4637)
Datasheet
Citations
Literature
Pathways

Biological Activity

Biotinylated Pam2CSK4 (Cat. No. 4637), a Toll-like receptor 2/6 agonist.

Technical Data

M. Wt 1724.44
Formula C87H162N14O16S2
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys), K6= aminocaproic acid-amonocaproic acid-biotin

Storage Store at -20°C
PubChem ID 90488960
InChI Key PGEYKKZJERUKGD-ZMWMYQNNSA-N
Smiles [H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@]2([H])NC(=O)N[C@]12[H])C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 1724.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.9 mL 5.8 mL
5 mM 0.12 mL 0.58 mL 1.16 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Latz et al (2007) Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat.Immunol. 8 772 PMID: 17572678


If you know of a relevant reference for Pam2CSK4 Biotin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Toll-like Receptor Agonists

Keywords: biotinylated Pam2CSK4 TLR2 TLR6 agonists Toll-like receptors Toll-like Receptors

Citations for Pam2CSK4 Biotin

Citations are publications that use Tocris products.

Currently there are no citations for Pam2CSK4 Biotin. Do you know of a great paper that uses Pam2CSK4 Biotin from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Pam2CSK4 Biotin

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

TODO: Add Protocols