Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 0.25% acetic acid|
Preparing Stock Solutions
The following data is based on the product molecular weight 1271.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.79 mL||3.93 mL||7.86 mL|
|5 mM||0.16 mL||0.79 mL||1.57 mL|
|10 mM||0.08 mL||0.39 mL||0.79 mL|
|50 mM||0.02 mL||0.08 mL||0.16 mL|
References are publications that support the biological activity of the product.
Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317
Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684
Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304
If you know of a relevant reference for Pam2CSK4, please let us know.
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Keywords: Pam2CSK4, Pam2CSK4 supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Receptors, 4637, Tocris Bioscience
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