Pam2CSK4

Pricing Availability   Qty
Cat.No. 4637 - Pam2CSK4 | Pam2-Cys-Ser-Lys-Lys-Lys-Lys | CAS No. 868247-72-7
Description: TLR2/6 agonist; induces TNF-α production
Datasheet
Citations (1)
Reviews (1)
Literature (2)
Pathways (1)

Biological Activity

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data

M. Wt 1271.83
Formula C65H126N10O12S
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Storage Store at -20°C
CAS Number 868247-72-7
PubChem ID 71457280
InChI Key LJUIOEFZFQRWJG-GHYFRYPYSA-N
Smiles [H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 0.25% acetic acid

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304


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Keywords: Pam2CSK4, Pam2CSK4 supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Receptors, 4637, Tocris Bioscience

1 Citation for Pam2CSK4

Citations are publications that use Tocris products. Selected citations for Pam2CSK4 include:

Hari et al (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5 eaaw0254 PMID: 31183403


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Reviews for Pam2CSK4

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Pam2CSK4 induces TNFa production and release.
By Anonymous on 12/12/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages

Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.

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Literature in this Area

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Cancer Research Product Guide

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Pathways for Pam2CSK4

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.