Pricing Availability   Qty
Description: TLR2/6 agonist; induces TNF-α production
Purity: ≥95% (HPLC)
Citations (3)
Reviews (1)
Literature (1)
Pathways (1)

Biological Activity for Pam2CSK4

Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data for Pam2CSK4

M. Wt 1271.83
Formula C65H126N10O12S
Sequence CSKKKK

(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 868247-72-7
PubChem ID 71457280

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pam2CSK4

Solubility Soluble to 1 mg/ml in 0.25% acetic acid

Product Datasheets for Pam2CSK4

Certificate of Analysis / Product Datasheet
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References for Pam2CSK4

References are publications that support the biological activity of the product.

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304

If you know of a relevant reference for Pam2CSK4, please let us know.

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Keywords: Pam2CSK4, Pam2CSK4 supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Receptors, 4637, Tocris Bioscience

3 Citations for Pam2CSK4

Citations are publications that use Tocris products. Selected citations for Pam2CSK4 include:

Hari et al (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5 eaaw0254 PMID: 31183403

Valerie G et al (2022) Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ 29 1267-1282 PMID: 34916628

Alexa et al (2023) Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells. Heliyon 9 e15202 PMID: 37123974

Do you know of a great paper that uses Pam2CSK4 from Tocris? Please let us know.

Reviews for Pam2CSK4

Average Rating: 5 (Based on 1 Review.)

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Pam2CSK4 induces TNFa production and release.
By Anonymous on 12/12/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages

Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Pam2CSK4

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.