Pam2CSK4

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Cat.No. 4637 - Pam2CSK4 | Pam2-Cys-Ser-Lys-Lys-Lys-Lys | CAS No. 868247-72-7
Description: TLR2/6 agonist; induces TNF-α production
Datasheet
Citations
Literature
Pathways

Biological Activity

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data

M. Wt 1271.83
Formula C65H126N10O12S
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Storage Store at -20°C
CAS Number 868247-72-7
PubChem ID 71457280
InChI Key LJUIOEFZFQRWJG-GHYFRYPYSA-N
Smiles [H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 0.25% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 1271.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.79 mL 3.93 mL 7.86 mL
5 mM 0.16 mL 0.79 mL 1.57 mL
10 mM 0.08 mL 0.39 mL 0.79 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304


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Keywords: TLR2 TLR6 agonists Toll-like receptors induces inducers TNF-a TNF-alpha TNF-α tumor tumour necrosis factor production Toll-like Receptors

Citations for Pam2CSK4

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
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  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
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Pathways for Pam2CSK4

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

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