Pricing Availability Delivery Time Qty
Cat.No. 4637 - Pam2CSK4 | Pam2-Cys-Ser-Lys-Lys-Lys-Lys | CAS No. 868247-72-7
Description: TLR2/6 agonist; induces TNF-α production

Biological Activity

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data

M. Wt 1271.83
Formula C65H126N10O12S
Sequence CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Storage Store at -20°C
CAS Number 868247-72-7
PubChem ID 71457280

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 0.25% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 1271.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.79 mL 3.93 mL 7.86 mL
5 mM 0.16 mL 0.79 mL 1.57 mL
10 mM 0.08 mL 0.39 mL 0.79 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304

If you know of a relevant reference for Pam2CSK4, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Toll-like Receptor Agonists

Keywords: Pam2CSK4, supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

Citations for Pam2CSK4

Citations are publications that use Tocris products.

Currently there are no citations for Pam2CSK4. Do you know of a great paper that uses Pam2CSK4 from Tocris? If so please let us know.

Reviews for Pam2CSK4

There are currently no reviews for this product. Be the first to review Pam2CSK4 and earn rewards!

Have you used Pam2CSK4?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Pam2CSK4

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.