P7C3

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Cat.No. 4076 - P7C3 | C21H18Br2N2O | CAS No. 301353-96-8
Description: NAMPT activator; also proneurogenic and neuroprotective
Chemical Name: 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.

Compound Libraries

P7C3 is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 474.19
Formula C21H18Br2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 301353-96-8
PubChem ID 2836187
InChI Key FZHHRERIIVOATI-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC1=C3N(CC(O)CNC4=CC=CC=C4)C2=C1C=C(Br)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 474.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.09 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pieper et al (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142 39 PMID: 20603013

Wang et al (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158 1324 PMID: 25215490


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Keywords: P7C3, supplier, P7C3, neuroprotective, neurogenesis, proneurogenic, NAMPT, Neural, Stem, Cells, NAMPT, Tocris Bioscience

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