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Description: NAMPT activator; also proneurogenic and neuroprotective
Chemical Name: 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for P7C3

P7C3 is a NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.

Compound Libraries for P7C3

P7C3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for P7C3

M. Wt 474.19
Formula C21H18Br2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 301353-96-8
PubChem ID 2836187
Smiles BrC(C=C3)=CC1=C3N(CC(O)CNC4=CC=CC=C4)C2=C1C=C(Br)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P7C3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.42 100

Preparing Stock Solutions for P7C3

The following data is based on the product molecular weight 474.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.09 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for P7C3

References are publications that support the biological activity of the product.

Pieper et al (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142 39 PMID: 20603013

Wang et al (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158 1324 PMID: 25215490

If you know of a relevant reference for P7C3, please let us know.

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Keywords: P7C3, P7C3 supplier, P7C3, neuroprotective, neurogenesis, proneurogenic, NAMPT, Neural, Stem, Cells, 4076, Tocris Bioscience

Citations for P7C3

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