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Selective, reversible competitive dipeptidyl peptidase IV (DP IV) inhibitor (Ki = 130 nM). Inhibits degradation of GIP and GLP-1, enhancing insulin secretion. Improves glucose tolerance, insulin sensitivity and b-cell glucose responsiveness in diabetic fatty rats following oral administration.
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|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47 1253 PMID: 9703325
Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral Ins sensitivity in the VDF Zucker rat. Diabetes 51 2677 PMID: 12196458
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Keywords: P32/98, P32/98 supplier, Isoleucyl, thiazolidide, Other, Proteases, 2136, Tocris Bioscience
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