Discontinued Product

Unfortunately P32/98 (Cat. No. 2136) has been withdrawn from sale for commercial reasons.
Cat.No. 2136 - P32/98 | CAS No. 136259-20-6
Description: Selective dipeptidyl peptidase IV inhibitor
Alternative Names: Isoleucyl thiazolidide
Chemical Name: (3N-[(2S,3S)-2-amino-3-methyl-pentanoyl]-1,3-thiazolidine) hemifumarate

Biological Activity

Selective, reversible competitive dipeptidyl peptidase IV (DP IV) inhibitor (Ki = 130 nM). Inhibits degradation of GIP and GLP-1, enhancing insulin secretion. Improves glucose tolerance, insulin sensitivity and b-cell glucose responsiveness in diabetic fatty rats following oral administration.

Licensing Information

Sold with the permission of Probiodrug.

Technical Data

M. Wt 260.35
Storage Desiccate at +4°C
CAS Number 136259-20-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 260.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.2 mL 38.41 mL
5 mM 0.77 mL 3.84 mL 7.68 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet


References are publications that support the products' biological activity.

Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47 1253 PMID: 9703325

Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat. Diabetes 51 2677 PMID: 12196458

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Keywords: P32/98, supplier, Isoleucyl, thiazolidide, Other, Proteases, Other, Proteases, Tocris Bioscience

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