Discontinued Product

P11 (Cat. No. 4744) has been withdrawn from sale for commercial reasons.
Description: Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
Citations (2)
Reviews (2)
Literature (2)

Biological Activity for P11

P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Technical Data for P11

M. Wt 720.78
Formula C30H48N12O9
Sequence HSDVHK

(Modifications: Lys-6 = C-terminal amide)

Storage Store at -20°C
CAS Number 848644-86-0
PubChem ID 90488969
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for P11

Certificate of Analysis / Product Datasheet
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References for P11

References are publications that support the biological activity of the product.

Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9 687 PMID: 15634795

Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10 72 PMID: 19882657

Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10 M110 PMID: 21558493

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: P11, P11 supplier, integrin, alpha, v, beta, 3, avb3, antagonists, vitronectin, potent, antiangiogenics, angiogenesis, Integrins, Cell, Adhesion, Molecules, Antiangiogenics, 4744, Tocris Bioscience

2 Citations for P11

Citations are publications that use Tocris products. Selected citations for P11 include:

Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Reviews for P11

Average Rating: 5 (Based on 2 Reviews.)

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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By Anonymous on 03/24/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat astroglioma C6 cells

alpha v beta 3 peptide antagonist P11 10 µg/ml

PMID: 29222114
review image

Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse brain endothelioma cell line

10 μg/ml

PMID: 27978828
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.