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Cat.No. 4744 - P11 | His-Ser-Asp-Val-His-Lys-NH2 | CAS No. 848644-86-0
Description: Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
Citations (1)

Biological Activity

Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Technical Data

M. Wt 720.78
Formula C30H48N12O9
Sequence HSDVHK

(Modifications: Lys-6 = C-terminal amide)

Storage Store at -20°C
CAS Number 848644-86-0
PubChem ID 90488969
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 720.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.94 mL 13.87 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the biological activity of the product.

Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9 687 PMID: 15634795

Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10 72 PMID: 19882657

Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10 M110 PMID: 21558493

If you know of a relevant reference for P11, please let us know.

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Keywords: P11, P11 supplier, integrin, alpha, v, beta, 3, avb3, antagonists, vitronectin, potent, antiangiogenics, angiogenesis, Integrins, Cell, Adhesion, Molecules, Antiangiogenics, 4744, Tocris Bioscience

1 Citation for P11

Citations are publications that use Tocris products. Selected citations for P11 include:

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Do you know of a great paper that uses P11 from Tocris? Please let us know.

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Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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  • Immune Cell Signaling
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