You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
(Modifications: Lys-6 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9 687 PMID: 15634795
Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10 72 PMID: 19882657
Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10 M110 PMID: 21558493
If you know of a relevant reference for P11, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: P11, P11 supplier, integrin, alpha, v, beta, 3, avb3, antagonists, vitronectin, potent, antiangiogenics, angiogenesis, Integrins, Cell, Adhesion, Molecules, Antiangiogenics, 4744, Tocris Bioscience
2 Citations for P11
Citations are publications that use Tocris products. Selected citations for P11 include:
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Do you know of a great paper that uses P11 from Tocris? Please let us know.
Reviews for P11
Average Rating: 5 (Based on 2 Reviews.)
Have you used P11?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
alpha v beta 3 peptide antagonist P11 10 µg/ml
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.