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Submit ReviewOrg 20599
Discontinued Product
Org 20599 (Cat. No. 2738) has been withdrawn from sale for commercial reasons.
Description: Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one
Biological Activity for Org 20599
Org 20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
Technical Data for Org 20599
| M. Wt | 438.04 |
| Formula | C25H40ClNO3 |
| Storage | Store at RT |
| CAS Number | 156685-94-8 |
| PubChem ID | 9850026 |
| InChI Key | NZFNABGZEQPYBX-PMBZPZLSSA-N |
| Smiles | O=[C@](CCl)[C@H]4CC[C@@]3([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@@](C)1[C@]([H])2CC[C@@]34C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Org 20599
References for Org 20599
References are publications that support the biological activity of the product.
Hill-Venning et al (1996) The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209 PMID: 9014136
Visser et al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo. J.Pharmacol.Exp.Ther. 303 616 PMID: 12388643
Weir et al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br.J.Anaesth. 92 704 PMID: 15033889
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Keywords: Org 20599, Org 20599 supplier, Positive, allosteric, modulators, direct, agonists, GABAA, receptors, Receptors, Org20599, PAM, 2738, Tocris Bioscience
Citations for Org 20599
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