Org 20599

Discontinued Product

Org 20599 (Cat. No. 2738) has been withdrawn from sale for commercial reasons.
Description: Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one
Literature (3)

Biological Activity for Org 20599

Org 20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Technical Data for Org 20599

M. Wt 438.04
Formula C25H40ClNO3
Storage Store at RT
CAS Number 156685-94-8
PubChem ID 9850026
Smiles O=[C@](CCl)[C@H]4CC[C@@]3([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Org 20599

References are publications that support the biological activity of the product.

Hill-Venning et al (1996) The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209 PMID: 9014136

Visser et al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo. J.Pharmacol.Exp.Ther. 303 616 PMID: 12388643

Weir et al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. Br.J.Anaesth. 92 704 PMID: 15033889

View Related Products by Target

View Related Products by Product Action

View all GABAA Receptor Modulators

Keywords: Org 20599, Org 20599 supplier, Positive, allosteric, modulators, direct, agonists, GABAA, receptors, Receptors, Org20599, PAM, 2738, Tocris Bioscience

Citations for Org 20599

Citations are publications that use Tocris products.

Currently there are no citations for Org 20599.

Reviews for Org 20599

There are currently no reviews for this product. Be the first to review Org 20599 and earn rewards!

Have you used Org 20599?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.