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Biological Activity for Omeprazole
Omeprazole is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).
Technical Data for Omeprazole
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Omeprazole
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Omeprazole
The following data is based on the product molecular weight 345.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.9 mL||14.48 mL||28.95 mL|
|5 mM||0.58 mL||2.9 mL||5.79 mL|
|10 mM||0.29 mL||1.45 mL||2.9 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References for Omeprazole
References are publications that support the biological activity of the product.
Satoh et al (1989) Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418
Richardson et al (1998) Proton pump inhibitors. Drugs 56 307 PMID: 9777309
Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360
Bojkova et al (2020) SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles. BioRxiv - Paper not yet peer reviewed.
If you know of a relevant reference for Omeprazole, please let us know.
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Keywords: Omeprazole, Omeprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, cytochrome, p450, CYP2C19, CYP2C9, CYP3A, SARS-CoV-2, COVID-19, severe, acute, respiratory, syndrome, H+,K+-ATPase, Cytochrome, P450, Coronavirus, 2583, Tocris Bioscience
Citations for Omeprazole
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Reviews for Omeprazole
Average Rating: 5 (Based on 1 Review.)
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We use it in the pharmacology lab for the assigment experiments
We prepare the solutions the same day of use