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Description: H+,K+-ATPase inhibitor
Chemical Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for Omeprazole

Omeprazole is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).

Technical Data for Omeprazole

M. Wt 345.42
Formula C17H19N3O3S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 73590-58-6
PubChem ID 4594
Smiles COC1=CC=C2N=C(NC2=C1)S(=O)CC1=C(C)C(OC)=C(C)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Omeprazole

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 17.27 50
DMSO 34.54 100

Preparing Stock Solutions for Omeprazole

The following data is based on the product molecular weight 345.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for Omeprazole

References are publications that support the biological activity of the product.

Satoh et al (1989) Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Richardson et al (1998) Proton pump inhibitors. Drugs 56 307 PMID: 9777309

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Bojkova et al (2020) SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles. BioRxiv - Paper not yet peer reviewed.

If you know of a relevant reference for Omeprazole, please let us know.

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Citations for Omeprazole

Citations are publications that use Tocris products.

Currently there are no citations for Omeprazole. Do you know of a great paper that uses Omeprazole from Tocris? Please let us know.

Reviews for Omeprazole

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Enzimes in the Lab.
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: blood

We use it in the pharmacology lab for the assigment experiments

We prepare the solutions the same day of use