OF 1

Pricing Availability   Qty
Description: Selective BRPF1B and BRPF2 inhibitor
Chemical Name: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for OF 1

OF 1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the OF 1 probe summary on the SGC website.

Compound Libraries for OF 1

OF 1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for OF 1

M. Wt 440.31
Formula C17H18BrN3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 919973-83-4
PubChem ID 35397514
InChI Key YUNQZQREIHWDQT-UHFFFAOYSA-N
Smiles CN1C2=C(C=C(OC)C(NS(C3=C(C)C=C(Br)C=C3)(=O)=O)=C2)N(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OF 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.81 20

Preparing Stock Solutions for OF 1

The following data is based on the product molecular weight 440.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.36 mL 56.78 mL 113.56 mL
1 mM 2.27 mL 11.36 mL 22.71 mL
2 mM 1.14 mL 5.68 mL 11.36 mL
10 mM 0.23 mL 1.14 mL 2.27 mL

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References for OF 1

References are publications that support the biological activity of the product.

Meier et al (2017) Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 12 2619 PMID: 28849908


If you know of a relevant reference for OF 1, please let us know.

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Keywords: OF 1, OF 1 supplier, OF1, selective, BRPF1B, BRPF2, bromodomain, inhibitors, inhibits, epigenetics, Bromodomains, 5289, Tocris Bioscience

Citations for OF 1

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Reviews for OF 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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