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Description: Selective BRPF1B and BRPF2 inhibitor
Chemical Name: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for OF 1
OF 1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the OF 1 probe summary on the SGC website.
Compound Libraries for OF 1
OF 1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for OF 1
| M. Wt | 440.31 |
| Formula | C17H18BrN3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 919973-83-4 |
| PubChem ID | 35397514 |
| InChI Key | YUNQZQREIHWDQT-UHFFFAOYSA-N |
| Smiles | CN1C2=C(C=C(OC)C(NS(C3=C(C)C=C(Br)C=C3)(=O)=O)=C2)N(C)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OF 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.81 | 20 |
Preparing Stock Solutions for OF 1
The following data is based on the product molecular weight 440.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.36 mL | 56.78 mL | 113.56 mL |
| 1 mM | 2.27 mL | 11.36 mL | 22.71 mL |
| 2 mM | 1.14 mL | 5.68 mL | 11.36 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
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Product Datasheets for OF 1
References for OF 1
References are publications that support the biological activity of the product.
Meier et al (2017) Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 12 2619 PMID: 28849908
If you know of a relevant reference for OF 1, please let us know.
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Keywords: OF 1, OF 1 supplier, OF1, selective, BRPF1B, BRPF2, bromodomain, inhibitors, inhibits, epigenetics, Bromodomains, 5289, Tocris Bioscience
Citations for OF 1
Citations are publications that use Tocris products.
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