Octopamine hydrochloride

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Cat.No. 2242 - Octopamine hydrochloride | C8H11NO2.HCl | CAS No. 770-05-8
Description: Invertebrate biogenic amine: activates β3 adrenoceptors
Alternative Names: (±)-p-Octopamine, Epirenor, Norfen
Chemical Name: α-(Aminomethyl)-4-hydroxybenzenemethanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3 receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A receptors, inhibiting subsequent cAMP production.

Technical Data

M. Wt 189.64
Formula C8H11NO2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 770-05-8
PubChem ID 20592
InChI Key PUMZXCBVHLCWQG-UHFFFAOYSA-N
Smiles Cl.NCC(O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.37 mL 52.73 mL
5 mM 1.05 mL 5.27 mL 10.55 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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References

References are publications that support the biological activity of the product.

Airriess et al (1997) Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor. Br.J.Pharmacol. 122 191 PMID: 9313925

Roeder (1999) Octopamine in invertebrates. Prog.Neurobiol. 59 533 PMID: 10515667

Visentin et al (2001) Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J.Pharmacol.Exp.Ther. 299 96 PMID: 11561068

Carpene et al (1999) Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn-Schmied.Arch.Pharmacol. 359 310


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1 Citation for Octopamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Octopamine hydrochloride include:

Li et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23 733 PMID: 28459438


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Literature in this Area

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