OctMAB

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Cat.No. 4225 - OctMAB | C21H46BrN | CAS No. 1120-02-1
Description: Dynamin inhibitor
Chemical Name: Octadecyltrimethylammonium bromide
Datasheet
Citations
Literature

Biological Activity

Dynamin inhibitor (IC50 = 1.9 μM for dynamin I). Inhibits receptor-mediated endocytosis (IC50 = 16 μM). Displays similar activity to MitMAB (Cat. No. 4224).

Technical Data

M. Wt 392.5
Formula C21H46BrN
Storage Desiccate at RT
CAS Number 1120-02-1
PubChem ID 70708
InChI Key SZEMGTQCPRNXEG-UHFFFAOYSA-M
Smiles CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.92 10
ethanol 39.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890

Joshi et al (2010) The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol.Cancer Ther. 9 1995 PMID: 20571068


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Keywords: dynamin I II inhibitors inhibits gtpase endocytosis OctMAB GTPase

Citations for OctMAB

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