OctMAB

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Cat.No. 4225 - OctMAB | C21H46BrN | CAS No. 1120-02-1
Description: Dynamin inhibitor
Chemical Name: Octadecyltrimethylammonium bromide
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Dynamin inhibitor (IC50 = 1.9 μM for dynamin I). Inhibits receptor-mediated endocytosis (IC50 = 16 μM). Displays similar activity to MitMAB (Cat. No. 4224).

Technical Data

M. Wt 392.5
Formula C21H46BrN
Storage Desiccate at RT
CAS Number 1120-02-1
PubChem ID 70708
InChI Key SZEMGTQCPRNXEG-UHFFFAOYSA-M
Smiles CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.92 10
ethanol 39.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890

Joshi et al (2010) The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol.Cancer Ther. 9 1995 PMID: 20571068


If you know of a relevant reference for OctMAB, please let us know.

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Keywords: OctMAB, OctMAB supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, OctMAB, Mitosis, Dynamin, 4225, Tocris Bioscience

1 Citation for OctMAB

Citations are publications that use Tocris products. Selected citations for OctMAB include:

Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463


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