Discontinued Product

Ocinaplon (Cat. No. 4410) has been withdrawn from sale for commercial reasons.
Description: GABAA modulator; anxiolytic
Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Ocinaplon

Ocinaplon is a modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.

Technical Data for Ocinaplon

M. Wt 301.3
Formula C17H11N5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 96604-21-6
PubChem ID 216456
Smiles O=C(C4=CC=CC=N4)C2=C1N=CC=C(C3=CC=NC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ocinaplon

References are publications that support the biological activity of the product.

Mirza et al (2006) Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, ZopiC., and various benzodiazepines in chlordiazep. and zol. drug discrimination. J.Pharmacol.Exp.Ther. 316 1291 PMID: 16339395

Lippa et al (2005) Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 102 7380 PMID: 15870187

Rupprecht et al (2006) GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 7 231 PMID: 17071543

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Keywords: Ocinaplon, Ocinaplon supplier, gabaa, α1, alpha1, a1, positive, modulators, anxiolytics, GABAA, Receptors, 4410, Tocris Bioscience

Citations for Ocinaplon

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Currently there are no citations for Ocinaplon.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.