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Description: Inactive analog of m-3M3FBS (Cat. No. 1941)
Chemical Name: 2,4,6-Trimethyl-N-[2-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity
Inactive analog of m-3M3FBS. Used as a negative control.
Active Analog also available.
Compound Libraries
o-3M3FBS is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 343.36 |
| Formula | C16H16F3NO2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 313981-55-4 |
| PubChem ID | 770820 |
| InChI Key | SKJJIFRWCCSXGL-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=C(C(C)=C1)S(=O)(=O)NC1=C(C=CC=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 34.34 | 100 | |
| DMSO | 34.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 343.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.91 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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References
References are publications that support the biological activity of the product.
Bae et al (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol.Pharmacol. 63 1043 PMID: 12695532
If you know of a relevant reference for o-3M3FBS, please let us know.
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Keywords: o-3M3FBS, o-3M3FBS supplier, Phospholipases, C, PLC, Esterases, activators, Phospholipase, 1942, Tocris Bioscience
6 Citations for o-3M3FBS
Citations are publications that use Tocris products. Selected citations for o-3M3FBS include:
Carim et al (2019) IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis. Curr Biol 29 775 PMID: 30799246
Szebenyi et al (2014) Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front Cell Neurosci 8 336 PMID: 25374507
Wilke et al (2014) Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nat Commun 5 5540 PMID: 25420509
Horowitz et al (2005) Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. PLoS One 126 243 PMID: 16129772
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol 143 3 PMID: 15302681
Semple-Rowland et al (2014) Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8 e83378 PMID: 24386190
Do you know of a great paper that uses o-3M3FBS from Tocris? Please let us know.
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