NVS MLLT-1

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Description: Selective MLLT1/3 inhibitor
Chemical Name: N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for NVS MLLT-1

NVS-MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3 (IC50 values are 150 and 254 nM for MLLT1 and MLLT3, respectively). It shows selectivity for YEATS2/4 domains and over all bromodomains (CERC2 IC50 > 40 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS MLLT-1 probe summary on the SGC website.

Technical Data for NVS MLLT-1

M. Wt 385.47
Formula C23H23N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2561471-13-2
PubChem ID 155925910
InChI Key ZRTFTZCKJUNZIU-HNNXBMFYSA-N
Smiles C[C@H]1CCCN1CC2=NC3=CC=C(C=C3N2)NC(C4=CC5=C(C=NC=C5)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NVS MLLT-1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.55 100
ethanol 19.27 50

Preparing Stock Solutions for NVS MLLT-1

The following data is based on the product molecular weight 385.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.97 mL 25.94 mL
5 mM 0.52 mL 2.59 mL 5.19 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for NVS MLLT-1

References are publications that support the biological activity of the product.

Ni et al (2021) Structure and inhibitor binding characterization of oncogenic MLLT1 mutants. ACS Chem.Biol. 16 571 PMID: 33749253


If you know of a relevant reference for NVS MLLT-1, please let us know.

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Keywords: NVS MLLT-1, NVS MLLT-1 supplier, NVSMLLT-1, inhibitors, inhibits, bromodomains, selective, mixed-lineage, leukemia, translocated, to, 1, MLLT1, MLLLT3, super, elongation, complex, subunit, YEATSdomain, Bromodomains, 7482, Tocris Bioscience

Citations for NVS MLLT-1

Citations are publications that use Tocris products.

Currently there are no citations for NVS MLLT-1. Do you know of a great paper that uses NVS MLLT-1 from Tocris? Please let us know.

Reviews for NVS MLLT-1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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