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NVS-MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3 (IC50 values are 150 and 254 nM for MLLT1 and MLLT3, respectively). It shows selectivity for YEATS2/4 domains and over all bromodomains (CERC2 IC50 > 40 μM).
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS MLLT-1 probe summary on the SGC website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 385.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.59 mL||12.97 mL||25.94 mL|
|5 mM||0.52 mL||2.59 mL||5.19 mL|
|10 mM||0.26 mL||1.3 mL||2.59 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
Ni et al (2021) Structure and inhibitor binding characterization of oncogenic MLLT1 mutants. ACS Chem.Biol. 16 571 PMID: 33749253
If you know of a relevant reference for NVS MLLT-1, please let us know.
Keywords: NVS MLLT-1, NVS MLLT-1 supplier, NVSMLLT-1, inhibitors, inhibits, bromodomains, selective, mixed-lineage, leukemia, translocated, to, 1, MLLT1, MLLLT3, super, elongation, complex, subunit, YEATSdomain, Bromodomains, 7482, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
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