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Selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.19||5 with gentle warming|
|ethanol||4.39||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.8 mL||113.99 mL||227.97 mL|
|0.5 mM||4.56 mL||22.8 mL||45.59 mL|
|1 mM||2.28 mL||11.4 mL||22.8 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
References are publications that support the biological activity of the product.
Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617
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Keywords: NSC 33994, NSC 33994 supplier, NSC33994, jak2, janus, tyrosine, kinase, inhibitors, inhibits, JAK, Kinase, 4338, Tocris Bioscience
1 Citation for NSC 33994
Citations are publications that use Tocris products. Selected citations for NSC 33994 include:
Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105
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