Selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.19||5mM with gentle warming|
|ethanol||4.39||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.4 mL||22.8 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617
If you know of a relevant reference for NSC 33994, please let us know.
View Related Products by Product Action
Keywords: NSC33994 jak2 janus tyrosine kinase inhibitors inhibits JAK Kinase
Citations for NSC 33994
Citations are publications that use Tocris products.
Currently there are no citations for NSC 33994. Do you know of a great paper that uses NSC 33994 from Tocris? If so please let us know.