Discontinued Product

NQTrp (Cat. No. 5398) has been withdrawn from sale for commercial reasons.
Description: Potent inhibitor of Aβ oligomer and fibril formation
Chemical Name: N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NQTrp

NQTrp is a potent inhibitor of Aβ oligomer and fibril formation (IC50 = 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβ oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-42.

Technical Data for NQTrp

M. Wt 360.36
Formula C21H16N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 185351-19-3
PubChem ID 56605052
Smiles O=C1C4=C(C=CC=C4)C(C(N[C@H]([C@@](O)=O)CC3=CNC2=CC=CC=C23)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NQTrp

References are publications that support the biological activity of the product.

Zhang et al (2013) Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem.Neurosci. 5 148 PMID: 24246047

Scherzer-Attali et al (2010) Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS ONE 5 e11101 PMID: 20559435

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Keywords: NQTrp, NQTrp supplier, amyloid, Abeta, AB, Aβ, inhibits, inhibitors, fibrils, oligomers, Alzheimer's, disease, Amyloid, Beta, Peptides, 5398, Tocris Bioscience

Citations for NQTrp

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Currently there are no citations for NQTrp.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.