Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
(Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 10% acetonitrile|
Preparing Stock Solutions
The following data is based on the product molecular weight 1381.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.72 mL||3.62 mL||7.24 mL|
|5 mM||0.14 mL||0.72 mL||1.45 mL|
|10 mM||0.07 mL||0.36 mL||0.72 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
References are publications that support the products' biological activity.
Calo et al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183 PMID: 10725267
Hashimoto et al (2000) Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neurosci.Lett. 278 109 PMID: 10643813
Pheng et al (2000) [Nphe1]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur.J.Pharmacol. 397 383 PMID: 10844138
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Keywords: [NPhe1]Nociceptin(1-13)NH2, supplier, Selective, competitive, nociceptin, antagonists, Receptors, ORL1, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
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