Discontinued Product

NPEC-caged-dopamine (Cat. No. 3992) has been withdrawn from sale for commercial reasons.
Cat.No. 3992 - NPEC-caged-dopamine | C17H18N2O6 | CAS No. 1257326-23-0
Description: Caged dopamine
Chemical Name: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine
Purity: ≥99% (HPLC)
Citations (2)
Literature (5)

Biological Activity for NPEC-caged-dopamine

NPEC-caged-dopamine is a NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine (Cat. No 3548); releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons.

Technical Data for NPEC-caged-dopamine

M. Wt 346.33
Formula C17H18N2O6
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1257326-23-0
PubChem ID 90488901
Smiles CC(OC(NCCC2=CC=C(O)C(O)=C2)=O)C1=C([N+]([O-])=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NPEC-caged-dopamine

Certificate of Analysis / Product Datasheet
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References for NPEC-caged-dopamine

References are publications that support the biological activity of the product.

Castro et al (2013) Striatal neurones have a specific ability to respond to phasic DA release. J.Physiol. 591 3197 PMID: 23551948

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Keywords: NPEC-caged-dopamine, NPEC-caged-dopamine supplier, caged, dopamine, compounds, neurotransmitters, D, receptors, dopaminergic, Caged, Dopamine, Compounds, D1, and, D5, Receptors, Non-selective, 3992, Tocris Bioscience

2 Citations for NPEC-caged-dopamine

Citations are publications that use Tocris products. Selected citations for NPEC-caged-dopamine include:

Yapo et al (2017) Detection of phasic DA by D1 and D2 striatal medium spiny neurons. J.Physiol. 595 7451 PMID: 28782235

Castro et al (2013) Striatal neurones have a specific ability to respond to phasic DA release. J.Physiol. 591 3197 PMID: 23551948

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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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