NPEC-caged-dopamine

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Cat.No. 3992 - NPEC-caged-dopamine | C17H18N2O6 | CAS No. 1257326-23-0
Description: Caged dopamine
Chemical Name: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine (Cat. No 3548); releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons.

Technical Data

M. Wt 346.33
Formula C17H18N2O6
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1257326-23-0
PubChem ID 90488901
InChI Key PDNNZLULXSQJGZ-UHFFFAOYSA-N
Smiles CC(OC(NCCC2=CC=C(O)C(O)=C2)=O)C1=C([N+]([O-])=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.63 100
ethanol 34.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 346.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.44 mL 28.87 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Castro et al (2013) Striatal neurones have a specific ability to respond to phasic dopamine release. J.Physiol. [Epub ahead of print] PMID: 23551948


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Citations for NPEC-caged-dopamine

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Pathways for NPEC-caged-dopamine

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