Nocistatin (human)

Pricing Availability Delivery Time Qty
Cat.No. 1198 - Nocistatin (human) | Met-Pro-Arg-Val-Arg-Ser-Leu-Phe-Gln-Glu-Gln-Glu-Glu-Pro-Glu-Pro-Gly-Met-Glu-Glu-Ala-Gly-Glu-Met-Glu-Gln-Lys-Gln-Leu-Gln | CAS No. 212609-11-5
Description: Human putative counterpart of nocistatin
Datasheet
Citations (1)
Literature

Biological Activity

Human putative counterpart of nocistatin (bovine). Blocks nociceptin-induced allodynia and hyperalgesia.

Technical Data

M. Wt 3561.93
Formula C149H238N42O53S3
Sequence MPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ
Storage Desiccate at -20°C
CAS Number 212609-11-5
PubChem ID 90479770
InChI Key OEZVAQPRAUPWHZ-FBGOCWIPSA-N
Smiles [H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 3561.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.28 mL 1.4 mL 2.81 mL
5 mM 0.06 mL 0.28 mL 0.56 mL
10 mM 0.03 mL 0.14 mL 0.28 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Minami et al (1998) Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br.J.Pharmacol. 124 1016 PMID: 9720768

Okuda-Ashitaka and Ito (2000) Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor. Peptides 21 1101 PMID: 10998544


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Keywords: Nocistatin (human), supplier, Human, putative, counterpart, nocistatin, Nociceptin, Receptors, ORL1, OP4, NOP, Opioid, antagonists, NOP, Receptors, NOP, Receptors, Tocris Bioscience

1 Citation for Nocistatin (human)

Citations are publications that use Tocris products. Selected citations for Nocistatin (human) include:

Laudenbach et al (2001) Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain. J Clin Invest 107 457 PMID: 11181645


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