Nocistatin (bovine)

Pricing Availability   Qty
Cat.No. 1118 - Nocistatin (bovine) | Thr-Glu-Pro-Gly-Leu-Glu-Glu-Val-Gly-Glu-Ile-Glu-Gln-Lys-Gln-Leu-Gln | CAS No. 208253-85-4
Description: Opposes action of nociceptin
Datasheet
Citations
Reviews
Literature

Biological Activity

An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.

Technical Data

M. Wt 1927.07
Formula C82H135N21O32
Sequence TEPGLEEVGEIEQKQLQ
Storage Desiccate at -20°C
CAS Number 208253-85-4
PubChem ID 24868191
InChI Key GUPWDFZVRDNEEX-GFTPUIGSSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in PBS

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fantin et al (2007) Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br.J.Pharmacol. 152 549 PMID: 17618307

Nicol et al (1998) Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices. Eur.J.Pharmacol. 356 R1 PMID: 9774260

Okuda-Ashitaka et al (1998) Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature 392 286 PMID: 9521323

Yamamoto et al (1999) Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. Neurosci.Lett. 262 179 PMID: 10218885


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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