Bioactive metabolite of nociceptin. Antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Montiel et al (1997) Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J.Neurochem. 68 354 PMID: 8978746
Sakurada et al (1999) Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice. Br.J.Pharmacol. 128 941 PMID: 10556929
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Keywords: Nociceptin (1-7), Nociceptin (1-7) supplier, Bioactive, metabolite, nociceptin, Receptors, ORL1, OP4, NOP, Opioid, 1266, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.