Bioactive metabolite of nociceptin. Antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 655.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.53 mL||7.63 mL||15.25 mL|
|5 mM||0.31 mL||1.53 mL||3.05 mL|
|10 mM||0.15 mL||0.76 mL||1.53 mL|
|50 mM||0.03 mL||0.15 mL||0.31 mL|
References are publications that support the products' biological activity.
Montiel et al (1997) Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J.Neurochem. 68 354 PMID: 8978746
Sakurada et al (1999) Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice. Br.J.Pharmacol. 128 941 PMID: 10556929
If you know of a relevant reference for Nociceptin (1-7), please let us know.
Keywords: Nociceptin (1-7), supplier, Bioactive, metabolite, nociceptin, Receptors, ORL1, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
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