Nociceptin (1-7)

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Cat.No. 1266 - Nociceptin (1-7) | Phe-Gly-Gly-Phe-Thr-Gly-Ala | CAS No. 178249-42-8
Description: Bioactive metabolite of nociceptin
Datasheet
Citations
Literature

Biological Activity

Bioactive metabolite of nociceptin. Antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia.

Technical Data

M. Wt 655.7
Formula C31H41N7O9
Sequence FGGFTGA
Storage Desiccate at -20°C
CAS Number 178249-42-8
PubChem ID 71353398
InChI Key KVTLKXLQUDUFSD-FLSSTNBBSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 655.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.63 mL 15.25 mL
5 mM 0.31 mL 1.53 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Montiel et al (1997) Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J.Neurochem. 68 354 PMID: 8978746

Sakurada et al (1999) Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice. Br.J.Pharmacol. 128 941 PMID: 10556929


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Keywords: Nociceptin (1-7), supplier, Bioactive, metabolite, nociceptin, Receptors, ORL1, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience

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