Nociceptin (1-13)NH2

Discontinued Product

Unfortunately Nociceptin (1-13)NH2 (Cat. No. 1358) has been withdrawn from sale for commercial reasons.
Cat.No. 1358 - Nociceptin (1-13)NH2 | Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2 | CAS No. 178064-02-3
Description: Potent ORL1 agonist
Datasheet
Citations (1)
Literature

Biological Activity

Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).

Technical Data

M. Wt 1381.6
Formula C61H100N22O15
Sequence FGGFTGARKSARK

(Modifications: Lys-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 178064-02-3
PubChem ID 6324645
InChI Key RHMALYOXPBRJBG-CGUXNFSNSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1381.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.72 mL 3.62 mL 7.24 mL
5 mM 0.14 mL 0.72 mL 1.45 mL
10 mM 0.07 mL 0.36 mL 0.72 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261 PMID: 10742280

Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485 PMID: 9884077

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Keywords: Nociceptin (1-13)NH2, supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience

1 Citation for Nociceptin (1-13)NH2

Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736


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