Discontinued ProductNociceptin (1-13)NH2 (Cat. No. 1358) has been withdrawn from sale for commercial reasons.
Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).
(Modifications: Lys-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261 PMID: 10742280
Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485 PMID: 9884077
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Keywords: Nociceptin (1-13)NH2, Nociceptin (1-13)NH2 supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, 1358, Tocris Bioscience
1 Citation for Nociceptin (1-13)NH2
Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.