Nociceptin (1-13)NH2

Discontinued Product

Nociceptin (1-13)NH2 (Cat. No. 1358) has been withdrawn from sale for commercial reasons.
Description: Potent ORL1 agonist
Citations (1)
Literature (1)

Biological Activity for Nociceptin (1-13)NH2

Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).

Technical Data for Nociceptin (1-13)NH2

M. Wt 1381.6
Formula C61H100N22O15

(Modifications: Lys-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 178064-02-3
PubChem ID 6324645
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Nociceptin (1-13)NH2

Certificate of Analysis / Product Datasheet
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References for Nociceptin (1-13)NH2

References are publications that support the biological activity of the product.

Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261 PMID: 10742280

Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485 PMID: 9884077

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Keywords: Nociceptin (1-13)NH2, Nociceptin (1-13)NH2 supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, 1358, Tocris Bioscience

1 Citation for Nociceptin (1-13)NH2

Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.