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Submit ReviewNociceptin (1-13)NH2
Discontinued Product
Nociceptin (1-13)NH2 (Cat. No. 1358) has been withdrawn from sale for commercial reasons.
Description: Potent ORL1 agonist
Biological Activity for Nociceptin (1-13)NH2
Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).
Technical Data for Nociceptin (1-13)NH2
| M. Wt | 1381.6 |
| Formula | C61H100N22O15 |
| Sequence |
FGGFTGARKSARK (Modifications: Lys-13 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 178064-02-3 |
| PubChem ID | 6324645 |
| InChI Key | RHMALYOXPBRJBG-CGUXNFSNSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nociceptin (1-13)NH2
References for Nociceptin (1-13)NH2
References are publications that support the biological activity of the product.
Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261 PMID: 10742280
Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485 PMID: 9884077
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Keywords: Nociceptin (1-13)NH2, Nociceptin (1-13)NH2 supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, 1358, Tocris Bioscience
1 Citation for Nociceptin (1-13)NH2
Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
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