Discontinued ProductUnfortunately Nociceptin (1-13)NH2 (Cat. No. 1358) has been withdrawn from sale for commercial reasons.
Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).
(Modifications: Lys-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1381.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.72 mL||3.62 mL||7.24 mL|
|5 mM||0.14 mL||0.72 mL||1.45 mL|
|10 mM||0.07 mL||0.36 mL||0.72 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
References are publications that support the products' biological activity.
Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261 PMID: 10742280
Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485 PMID: 9884077
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Keywords: Nociceptin (1-13)NH2, supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
1 Citation for Nociceptin (1-13)NH2
Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
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