NNC 63-0532

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Cat.No. 1780 - NNC 63-0532 | C27H29N3O3 | CAS No. 250685-44-0
Description: Potent non-peptide NOP agonist; brain penetrant
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.

Compound Libraries

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Technical Data

M. Wt 443.54
Formula C27H29N3O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 250685-44-0
PubChem ID 3906780
InChI Key DSEIKQVUTKGLGT-UHFFFAOYSA-N
Smiles COC(=O)CN1CN(C2=CC=CC=C2)C2(CCN(CC3=CC=C4C=CC=CC4=C3)CC2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.22 5
DMSO 22.18 50

Preparing Stock Solutions

The following data is based on the product molecular weight 443.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.55 mL 45.09 mL
2.5 mM 0.9 mL 4.51 mL 9.02 mL
5 mM 0.45 mL 2.25 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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References

References are publications that support the biological activity of the product.

Thomsen and Hohlweg (2000) (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 131 903 PMID: 11053209


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Keywords: NNC 63-0532, NNC 63-0532 supplier, Potent, non-peptide, NOP, agonists, brain, penetrant, Nociceptin, Receptors, ORL1, OP4, Opioid, NNC630532, 1780, Tocris Bioscience

1 Citation for NNC 63-0532

Citations are publications that use Tocris products. Selected citations for NNC 63-0532 include:

Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139 PMID: 24188792


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