Potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 443.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.25 mL||11.27 mL||22.55 mL|
|5 mM||0.45 mL||2.25 mL||4.51 mL|
|10 mM||0.23 mL||1.13 mL||2.25 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References are publications that support the products' biological activity.
Thomsen and Hohlweg (2000) (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 131 903 PMID: 11053209
If you know of a relevant reference for NNC 63-0532, please let us know.
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Keywords: NNC 63-0532, supplier, Potent, non-peptide, NOP, agonists, brain, penetrant, Nociceptin, Receptors, ORL1, OP4, Opioid, NNC630532, NOP, Receptors, NOP, Receptors, Tocris Bioscience
1 Citation for NNC 63-0532
Citations are publications that use Tocris products. Selected citations for NNC 63-0532 include:
Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139 PMID: 24188792
Do you know of a great paper that uses NNC 63-0532 from Tocris? If so please let us know.
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