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Submit ReviewNNC 63-0532
Description: Potent non-peptide NOP agonist; brain penetrant
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Purity: ≥98% (HPLC)
Biological Activity for NNC 63-0532
NNC 63-0532 is a potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
Compound Libraries for NNC 63-0532
NNC 63-0532 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NNC 63-0532
| M. Wt | 443.54 |
| Formula | C27H29N3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 250685-44-0 |
| PubChem ID | 3906780 |
| InChI Key | DSEIKQVUTKGLGT-UHFFFAOYSA-N |
| Smiles | COC(=O)CN1CN(C2=CC=CC=C2)C2(CCN(CC3=CC=C4C=CC=CC4=C3)CC2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NNC 63-0532
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 2.22 | 5 | |
| DMSO | 22.18 | 50 |
Preparing Stock Solutions for NNC 63-0532
The following data is based on the product molecular weight 443.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.51 mL | 22.55 mL | 45.09 mL |
| 2.5 mM | 0.9 mL | 4.51 mL | 9.02 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.9 mL |
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Product Datasheets for NNC 63-0532
References for NNC 63-0532
References are publications that support the biological activity of the product.
Thomsen and Hohlweg (2000) (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 131 903 PMID: 11053209
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Keywords: NNC 63-0532, NNC 63-0532 supplier, Potent, non-peptide, NOP, agonists, brain, penetrant, Nociceptin, Receptors, ORL1, OP4, Opioid, NNC630532, 1780, Tocris Bioscience
1 Citation for NNC 63-0532
Citations are publications that use Tocris products. Selected citations for NNC 63-0532 include:
Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139 PMID: 24188792
Do you know of a great paper that uses NNC 63-0532 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.