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Description: CaV1.x blocker
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid ethyl methyl ester
Purity: ≥99% (HPLC)
Citations (3)
Reviews (1)

Biological Activity for Nitrendipine

Nitrendipine is a L-type calcium channel blocker. Induces autophagy.

Technical Data for Nitrendipine

M. Wt 360.37
Formula C18H20N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 39562-70-4
PubChem ID 4507
Smiles CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nitrendipine

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 25

Preparing Stock Solutions for Nitrendipine

The following data is based on the product molecular weight 360.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.55 mL 27.75 mL 55.5 mL
2.5 mM 1.11 mL 5.55 mL 11.1 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
25 mM 0.11 mL 0.55 mL 1.11 mL

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References for Nitrendipine

References are publications that support the biological activity of the product.

Costa et al (1996) Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain. Neurochem.Res. 21 537 PMID: 8726959

Watanabe et al (1995) L-type calcium channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts. J.Mol.Cell.Cardiol. 27 1271 PMID: 8531209

Merck Index 12 6667

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513

If you know of a relevant reference for Nitrendipine, please let us know.

View Related Products by Product Action

View all CaV1.x Channel (L-type) Blockers

Keywords: Nitrendipine, Nitrendipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Cav1.x, Autophagy, 0601, Tocris Bioscience

3 Citations for Nitrendipine

Citations are publications that use Tocris products. Selected citations for Nitrendipine include:

Subramanian and Morozov (2011) Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci 31 4755 PMID: 21430174

Rosenkranz et al (2009) Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res 83 778 PMID: 19460777

Schmitz et al (2009) Glutamate controls growth rate and branching of DArgic axons. J Neurosci 29 11973 PMID: 19776283

Do you know of a great paper that uses Nitrendipine from Tocris? Please let us know.

Reviews for Nitrendipine

Average Rating: 5 (Based on 1 Review.)

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Nitrendipine was measured against other calcium channel blockers.
By Anonymous on 02/20/2019
Species: Human

Nitrendipine blocks L-type calcium channels in smooth muscle cells and its effectiveness was measured against other calcium channel blockers.

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