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Nitrendipine is a L-type calcium channel blocker. Induces autophagy.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 360.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.55 mL||27.75 mL||55.5 mL|
|2.5 mM||1.11 mL||5.55 mL||11.1 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|25 mM||0.11 mL||0.55 mL||1.11 mL|
References are publications that support the biological activity of the product.
Costa et al (1996) Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain. Neurochem.Res. 21 537 PMID: 8726959
Watanabe et al (1995) L-type calcium channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts. J.Mol.Cell.Cardiol. 27 1271 PMID: 8531209
Merck Index 12 6667
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513
If you know of a relevant reference for Nitrendipine, please let us know.
Keywords: Nitrendipine, Nitrendipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Cav1.x, Autophagy, 0601, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Nitrendipine include:
Schmitz et al (2009) Glutamate controls growth rate and branching of DArgic axons. J Neurosci 29 11973 PMID: 19776283
Rosenkranz et al (2009) Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res 83 778 PMID: 19460777
Subramanian and Morozov (2011) Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci 31 4755 PMID: 21430174
Do you know of a great paper that uses Nitrendipine from Tocris? Please let us know.
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