Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||23.68 mL||118.38 mL||236.76 mL|
|1 mM||4.74 mL||23.68 mL||47.35 mL|
|2 mM||2.37 mL||11.84 mL||23.68 mL|
|10 mM||0.47 mL||2.37 mL||4.74 mL|
References are publications that support the biological activity of the product.
Shindo et al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985 PMID: 9692785
Horinaka et al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200 PMID: 11483869
Gomma et al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705 PMID: 11693460
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Keywords: Nicorandil, Nicorandil supplier, KATP, channel, openers, NO, donor, Potassium, KIR, Channels, Inward, Rectifier, K+, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Kir6, rectifier, /, 2147, Tocris Bioscience
1 Citation for Nicorandil
Citations are publications that use Tocris products. Selected citations for Nicorandil include:
Killeen et al (2008) Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 193 25 PMID: 18005217
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Reviews for Nicorandil
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Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.
Literature in this Area
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