Nicorandil

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Cat.No. 2147 - Nicorandil | C8H9N3O4 | CAS No. 65141-46-0
Description: Kir6 (KATP) channel opener and NO donor
Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

M. Wt 211.18
Formula C8H9N3O4
Storage Desiccate at +4°C
CAS Number 65141-46-0
PubChem ID 47528
InChI Key LBHIOVVIQHSOQN-UHFFFAOYSA-N
Smiles [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.22 20

Preparing Stock Solutions

The following data is based on the product molecular weight 211.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.74 mL 23.68 mL 47.35 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.74 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Shindo et al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985 PMID: 9692785

Horinaka et al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200 PMID: 11483869

Gomma et al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705 PMID: 11693460


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Keywords: Nicorandil, Nicorandil supplier, KATP, channel, openers, NO, donor, Potassium, KIR, Channels, Inward, Rectifier, K+, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Kir6, rectifier, /, 2147, Tocris Bioscience

1 Citation for Nicorandil

Citations are publications that use Tocris products. Selected citations for Nicorandil include:

Killeen et al (2008) Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 193 25 PMID: 18005217


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Literature in this Area

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