Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Chemical Name: (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)

Biological Activity for NICE 01

NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.

Technical Data for NICE 01

M. Wt 1206.85
Formula C63H76ClN7O13S
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 169183208
Smiles O=C(O[C@H](CCC1=CC=C(C(OC)=C1)OC)C2=CC=CC(OCC(NCCOCCOCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)=O)=C2)[C@H]7N(CCCC7)C([C@@H](CC)C8=CC(OC)=C(C(OC)=C8)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NICE 01

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 60.34 50

Preparing Stock Solutions for NICE 01

The following data is based on the product molecular weight 1206.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.66 mL 8.29 mL 16.57 mL
2.5 mM 0.33 mL 1.66 mL 3.31 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
25 mM 0.03 mL 0.17 mL 0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for NICE 01

References are publications that support the biological activity of the product.

Lu et al (2022) Bioorthogonal chemical epigenetic modifiers enable dose-dependent CRISPR targeted gene activation in mammalian cells. A.C.S.Synth.Biol. 11 1397 PMID: 35302756

Gibson et al (2023) Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. J.Am.Chem.Soc. 145 26028 PMID: 37461636

If you know of a relevant reference for NICE 01, please let us know.

View Related Products by Target

Keywords: NICE 01, NICE 01 supplier, CEM207, FKBPF36V, tagged, proteins, BRD4, FKBP, NICE-01, NICE01, Protein, Dimerizers, 8088, Tocris Bioscience

Citations for NICE 01

Citations are publications that use Tocris products.

Currently there are no citations for NICE 01. Do you know of a great paper that uses NICE 01 from Tocris? Please let us know.

Reviews for NICE 01

There are currently no reviews for this product. Be the first to review NICE 01 and earn rewards!

Have you used NICE 01?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review