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Description: Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
Chemical Name: 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Nexinhib20

Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.

Compound Libraries for Nexinhib20

Nexinhib20 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nexinhib20

M. Wt 300.31
Formula C15H16N4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 331949-35-0
PubChem ID 5715188
Smiles CC(C)(C(/C(N1C=NC=N1)=C/C2=CC([N+]([O-])=O)=CC=C2)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nexinhib20

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.03 100

Preparing Stock Solutions for Nexinhib20

The following data is based on the product molecular weight 300.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.3 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets for Nexinhib20

Certificate of Analysis / Product Datasheet
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References for Nexinhib20

References are publications that support the biological activity of the product.

Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998

If you know of a relevant reference for Nexinhib20, please let us know.

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Keywords: Nexinhib20, Nexinhib20 supplier, Rab27, inhibitors, inhibits, Rab27a-JFC1, binding, neutrophil-specific, exocytosis, anti-inflammatory, Nexinhib, 20, Other, Small, Monomeric, GTPases, 6089, Tocris Bioscience

1 Citation for Nexinhib20

Citations are publications that use Tocris products. Selected citations for Nexinhib20 include:

Jong-Hyuk et al (2020) Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth. Int J Mol Sci 21 PMID: 32784729

Do you know of a great paper that uses Nexinhib20 from Tocris? Please let us know.

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