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Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 300.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.33 mL||16.65 mL||33.3 mL|
|5 mM||0.67 mL||3.33 mL||6.66 mL|
|10 mM||0.33 mL||1.66 mL||3.33 mL|
|50 mM||0.07 mL||0.33 mL||0.67 mL|
References are publications that support the biological activity of the product.
Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998
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Keywords: Nexinhib20, Nexinhib20 supplier, Rab27, inhibitors, inhibits, Rab27a-JFC1, binding, neutrophil-specific, exocytosis, anti-inflammatory, Nexinhib, 20, Other, Small, Monomeric, GTPases, 6089, Tocris Bioscience
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