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Submit ReviewNAV 26 is a selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
NAV 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 434.41 |
Formula | C22H21F3N2O4 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1198160-14-3 |
PubChem ID | 44540282 |
InChI Key | ICGMZCVSHDKQTE-UHFFFAOYSA-N |
Smiles | O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.44 | 100 | |
ethanol | 21.72 | 50 |
The following data is based on the product molecular weight 434.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.3 mL | 11.51 mL | 23.02 mL |
5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
10 mM | 0.23 mL | 1.15 mL | 2.3 mL |
50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
References are publications that support the biological activity of the product.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID: 22770500
If you know of a relevant reference for NAV 26, please let us know.
Keywords: NAV 26, NAV 26 supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Voltage-gated, Sodium, Channels, 4691, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for NAV 26 include:
Dandan et al (2017) Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep 16 2269-2273 PMID: 28627683
Do you know of a great paper that uses NAV 26 from Tocris? Please let us know.
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