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Selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.
Sold with the permission of the University of Minnesota
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||25.58||50 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.91 mL||19.55 mL||39.09 mL|
|2.5 mM||0.78 mL||3.91 mL||7.82 mL|
|5 mM||0.39 mL||1.95 mL||3.91 mL|
|25 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the biological activity of the product.
Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of mor. dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738
Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846
Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992
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Keywords: Naltriben mesylate, Naltriben mesylate supplier, δ2-opioid, delta2-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0892, Tocris Bioscience
1 Citation for Naltriben mesylate
Citations are publications that use Tocris products. Selected citations for Naltriben mesylate include:
Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol 20 RC110 PMID: 11069979
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.