Naltriben mesylate

Pricing Availability Delivery Time Qty
Cat.No. 0892 - Naltriben mesylate | C26H25NO4.CH3SO3H | CAS No. 122517-78-6
Description: Standard δ2 selective antagonist
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Datasheet
Citations (1)
Literature

Biological Activity

Selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.

Licensing Information

Sold with the permission of the University of Minnesota

Compound Libraries

Naltriben mesylate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 511.59
Formula C26H25NO4.CH3SO3H
Storage Desiccate at RT
CAS Number 122517-78-6
PubChem ID 45073482
InChI Key XRRFZOCDAWPIBB-XXCZMEBESA-N
Smiles CS(=O)(O)=O.O[C@@]24[C@]3([C@@H]7C(O6)=C(C5=C6C=CC=C5)C4)C1=C(O7)C(O)=CC=C1CC2N(CC8CC8)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.58 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.55 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of morphine dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738

Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846

Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992


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View all δ Opioid Receptor Antagonists

Keywords: δ2-opioid delta2-opioid selective antagonists DOP Receptors OP1 Delta Opioid Receptors

1 Citation for Naltriben mesylate

Citations are publications that use Tocris products. Selected citations for Naltriben mesylate include:

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol 20 RC110 PMID: 11069979


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