Naltriben mesylate

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Cat.No. 0892 - Naltriben mesylate | C26H25NO4.CH3SO3H | CAS No. 122517-78-6
Description: Standard δ2 selective antagonist
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data

M. Wt 511.59
Formula C26H25NO4.CH3SO3H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 122517-78-6
PubChem ID 45073482
InChI Key XRRFZOCDAWPIBB-IDRHMUJXSA-N
Smiles C[S](O)(=O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CC1=C2OC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.58 50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 511.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.91 mL 19.55 mL 39.09 mL
2.5 mM 0.78 mL 3.91 mL 7.82 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of mor. dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738

Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846

Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992


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Keywords: Naltriben mesylate, Naltriben mesylate supplier, δ2-opioid, delta2-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0892, Tocris Bioscience

1 Citation for Naltriben mesylate

Citations are publications that use Tocris products. Selected citations for Naltriben mesylate include:

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol 20 RC110 PMID: 11069979


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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