Naltriben mesylate

Discontinued Product

Naltriben mesylate (Cat. No. 0892) has been withdrawn from sale for commercial reasons.
Description: Standard δ2 selective antagonist
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Naltriben mesylate

Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data for Naltriben mesylate

M. Wt 511.59
Formula C26H25NO4.CH3SO3H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 122517-78-6
PubChem ID 45073482
Smiles C[S](O)(=O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CC1=C2OC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Naltriben mesylate

Certificate of Analysis / Product Datasheet
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References for Naltriben mesylate

References are publications that support the biological activity of the product.

Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of mor. dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738

Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846

Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992

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Keywords: Naltriben mesylate, Naltriben mesylate supplier, δ2-opioid, delta2-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0892, Tocris Bioscience

1 Citation for Naltriben mesylate

Citations are publications that use Tocris products. Selected citations for Naltriben mesylate include:

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol 20 RC110 PMID: 11069979

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.