Naloxone fluorescein acetate

Pricing Availability Delivery Time Qty
Cat.No. 6046 - Naloxone fluorescein acetate | C40H34N4O8S.C2H4O2
Description: Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)
Chemical Name: N-(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazinecarbothioamide acetate
Datasheet
Citations
Literature

Biological Activity

Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599). Excitation\emission λ ~ 492\517 nm at pH 10.

Technical Data

M. Wt 790.84
Formula C40H34N4O8S.C2H4O2
Storage Store at -20°C
PubChem ID 122705994
InChI Key DRNYJSGWOSUNLJ-KYTOOIOKSA-N
Smiles [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\NC(NC6=CC=C7C(C(OC78C9=CC=C(C=C9OC%10=CC(O)=CC=C8%10)O)=O)=C6)=S)O)[H])CC=C)O.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.5 1

Preparing Stock Solutions

The following data is based on the product molecular weight 790.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.26 mL 6.32 mL 12.64 mL
5 mM 0.25 mL 1.26 mL 2.53 mL
10 mM 0.13 mL 0.63 mL 1.26 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Friesen et al (2014) Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell Cycle 13 1560 PMID: 24626197


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Keywords: Naloxone fluorescein acetate, supplier, Fluorescent, opioid, receptor, antagonists, antagonism, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

Citations for Naloxone fluorescein acetate

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