Naloxone fluorescein acetate

Discontinued Product

Naloxone fluorescein acetate (Cat. No. 6046) has been withdrawn from sale for commercial reasons.
Description: Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)
Chemical Name: N-(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazinecarbothioamide acetate
Literature (2)

Biological Activity for Naloxone fluorescein acetate

Naloxone fluorescein acetate is a fluorescent opioid antagonist; fluorescent derivative of naloxone (Cat. No. 0599). Excitation\emission λ ~ 492\517 nm at pH 10.

Technical Data for Naloxone fluorescein acetate

M. Wt 790.84
Formula C40H34N4O8S.C2H4O2
Storage Store at -20°C
CAS Number 2080300-52-1
PubChem ID 122705994
Smiles [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\NC(NC6=CC=C7C(C(OC78C9=CC=C(C=C9OC%10=CC(O)=CC=C8%10)O)=O)=C6)=S)O)[H])CC=C)O.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Naloxone fluorescein acetate

Certificate of Analysis / Product Datasheet
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References for Naloxone fluorescein acetate

References are publications that support the biological activity of the product.

Friesen et al (2014) Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell Cycle 13 1560 PMID: 24626197

Keywords: Naloxone fluorescein acetate, Naloxone fluorescein acetate supplier, Fluorescent, opioid, receptor, antagonists, antagonism, Miscellaneous/Non-selective, Opioids, Receptor, Probes, 6046, Tocris Bioscience

Citations for Naloxone fluorescein acetate

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Currently there are no citations for Naloxone fluorescein acetate.

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

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Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.