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Naloxone fluorescein acetate

Cat. No. 6046 Submit a Review Datasheet / COA / SDS
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Description: Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)
Chemical Name: N-(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazinecarbothioamide acetate
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Citations
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Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Naloxone fluorescein acetate

Naloxone fluorescein acetate is a fluorescent opioid antagonist; fluorescent derivative of naloxone (Cat. No. 0599). Excitation\emission λ ~ 492\517 nm at pH 10.

Technical Data for Naloxone fluorescein acetate

M. Wt 790.84
Formula C40H34N4O8S.C2H4O2
Storage Store at -20°C
CAS Number 2080300-52-1
PubChem ID 122705994
InChI Key DRNYJSGWOSUNLJ-KYTOOIOKSA-N
Smiles [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\NC(NC6=CC=C7C(C(OC78C9=CC=C(C=C9OC%10=CC(O)=CC=C8%10)O)=O)=C6)=S)O)[H])CC=C)O.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Naloxone fluorescein acetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.5 1

Preparing Stock Solutions for Naloxone fluorescein acetate

The following data is based on the product molecular weight 790.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 126.45 mL 632.24 mL 1264.48 mL
0.05 mM 25.29 mL 126.45 mL 252.9 mL
0.1 mM 12.64 mL 63.22 mL 126.45 mL
0.5 mM 2.53 mL 12.64 mL 25.29 mL

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Product Datasheets for Naloxone fluorescein acetate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Naloxone fluorescein acetate

References are publications that support the biological activity of the product.

Friesen et al (2014) Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell Cycle 13 1560 PMID: 24626197

If you know of a relevant reference for Naloxone fluorescein acetate, please let us know.

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Keywords: Naloxone fluorescein acetate, Naloxone fluorescein acetate supplier, Fluorescent, opioid, receptor, antagonists, antagonism, Miscellaneous/Non-selective, Opioids, Receptor, Probes, 6046, Tocris Bioscience

Citations for Naloxone fluorescein acetate

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
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  • TSA VividTM Fluorophore Kits
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Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.