Naloxone fluorescein acetate

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Cat.No. 6046 - Naloxone fluorescein acetate | C40H34N4O8S.C2H4O2
Description: Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)
Chemical Name: N-(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazinecarbothioamide acetate
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599). Excitation\emission λ ~ 492\517 nm at pH 10.

Technical Data

M. Wt 790.84
Formula C40H34N4O8S.C2H4O2
Storage Store at -20°C
PubChem ID 122705994
InChI Key DRNYJSGWOSUNLJ-KYTOOIOKSA-N
Smiles [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\NC(NC6=CC=C7C(C(OC78C9=CC=C(C=C9OC%10=CC(O)=CC=C8%10)O)=O)=C6)=S)O)[H])CC=C)O.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.5 1

Preparing Stock Solutions

The following data is based on the product molecular weight 790.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 126.45 mL 632.24 mL 1264.48 mL
0.05 mM 25.29 mL 126.45 mL 252.9 mL
0.1 mM 12.64 mL 63.22 mL 126.45 mL
0.5 mM 2.53 mL 12.64 mL 25.29 mL

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References

References are publications that support the biological activity of the product.

Friesen et al (2014) Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell Cycle 13 1560 PMID: 24626197


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Keywords: Naloxone fluorescein acetate, Naloxone fluorescein acetate supplier, Fluorescent, opioid, receptor, antagonists, antagonism, Miscellaneous/Non-selective, Opioids, Receptor, Probes, 6046, Tocris Bioscience

Citations for Naloxone fluorescein acetate

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Literature in this Area

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Enabling Research By Provision of Chemical Tools

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.