Nalmefene hydrochloride

Pricing Availability   Qty
Description: Opioid receptor antagonist
Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Nalmefene hydrochloride

Nalmefene hydrochloride is an opioid receptor antagonist; displays a longer half life than Naloxone. Exhibits neuroprotective effects after traumatic brain injury in the rat.

Compound Libraries for Nalmefene hydrochloride

Nalmefene hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nalmefene hydrochloride

M. Wt 375.89
Formula C21H25NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 58895-64-0
PubChem ID 5388881
Smiles C=C3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(CC6CC6)CC4)[C@@](O)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nalmefene hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 37.59 100
DMSO 37.59 100

Preparing Stock Solutions for Nalmefene hydrochloride

The following data is based on the product molecular weight 375.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.3 mL 26.6 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for Nalmefene hydrochloride

Certificate of Analysis / Product Datasheet
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References for Nalmefene hydrochloride

References are publications that support the biological activity of the product.

Vink et al (1990) Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats. J.Neurosci. 10 3524 PMID: 2230942

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Citations for Nalmefene hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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