Nalmefene hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4085 - Nalmefene hydrochloride | C21H25NO3.HCl | CAS No. 58895-64-0
Description: Opioid receptor antagonist
Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Opioid receptor antagonist; displays a longer half life than Naloxone (Cat. No. 0599). Exhibits neuroprotective effects after traumatic brain injury in the rat. Deuterated version, Nalmefene d3 (Cat. No. 3971), also available.

Compound Libraries

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Technical Data

M. Wt 375.89
Formula C21H25NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 58895-64-0
PubChem ID 5388881
InChI Key GYWMRGWFQPSQLK-OPHZJPRHSA-N
Smiles C=C3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(CC6CC6)CC4)[C@@](O)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.59 100
water 37.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 375.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.3 mL 26.6 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Vink et al (1990) Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats. J.Neurosci. 10 3524 PMID: 2230942


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Keywords: Nalmefene hydrochloride, supplier, opioid, receptor, antagonist, antagonists, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

Citations for Nalmefene hydrochloride

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