NAI-N3

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Cat.No. 7003 - NAI-N3 | C10H8N6O | CAS No. 1612756-29-2
Description: Reagent for RNA icSHAPE experiments in vivo
Chemical Name: [2-(Azidomethyl)-3-pyridinyl]-1H-imidazol-1-ylmethanone
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

NAI-N3 is a probe for icSHAPE (in vivo click selective 2'-hydroxyl acylation and profiling experiment). Acylates the 2'-OH in ssRNA. Enables RNA structure profiling in vivo and ex vivo for all four bases. NAI-N3 can be used for site-specific RNA acylation using the RAIL (RNA Acylation at Induced Loops) method or in Apta-Seq to discover new aptamers in selected pools.

Technical Data

M. Wt 228.22
Formula C10H8N6O
Storage Store at -20°C
CAS Number 1612756-29-2
PubChem ID 131704490
InChI Key QPSQVTFTPHUCEH-UHFFFAOYSA-N
Smiles [N-]=[N+]=NCC1=C(C(N2C=CN=C2)=O)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 1M)

References

References are publications that support the biological activity of the product.

Spitale et al (2015) Structural imprints in vivo decode RNA regulatory mechanisms. Nature 519 486 PMID: 25799993

Lee et al (2017) Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA 23 169 PMID: 27879433

Xiao et al (2020) Site-selective RNA functionalization via DNA-induced structure. J.Am.Chem.Soc. 142 16357 PMID: 32865995

Abdelsayed et al (2017) Multiplex aptamer discovery through Apta-Seq and its application to ATP aptamers derived from human-genomic SELEX. ACS Chem.Biol. 12 2149 PMID: 28661647


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Keywords: NAI-N3, NAI-N3 supplier, icSHAPE, RNA, reagent, probe, in, vivo, click, selective, 2prime, -hydroxyl, acylation, and, profiling, experiment, Apta-Seq, RAIL, DNA,, Protein, Synthesis, Biochemicals, Molecular, Biology, 7003, Tocris Bioscience

Citations for NAI-N3

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