N-Acetyl-L-leucyl-L-leucyl-L-methional

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Cat.No. 0384 - N-Acetyl-L-leucyl-L-leucyl-L-methional | C19H35N3O4S | CAS No. 136632-32-1
Description: Cathepsin inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data

M. Wt 401.56
Formula C19H35N3O4S
Storage Store at -20°C
CAS Number 136632-32-1
PubChem ID 4331
InChI Key RJWLAIMXRBDUMH-UHFFFAOYSA-N
Smiles O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.02 10
DMSO 40.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.9 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961 PMID: 9169469

Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636


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Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, N-Acetyl-L-leucyl-L-leucyl-L-methional supplier, Cathepsin, L, B, inhibitors, inhibits, Proteinases, Proteases, Acetylleucylleucylmethional, Calcium-Sensitive, 0384, Tocris Bioscience

Citations for N-Acetyl-L-leucyl-L-leucyl-L-methional

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Literature in this Area

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