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Discontinued ProductThis product has been withdrawn from sale and is superseded by E 64d (Cat. No. 4545)
Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961 PMID: 9169469
Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636
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Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, N-Acetyl-L-leucyl-L-leucyl-L-methional supplier, Cathepsin, L, B, inhibitors, inhibits, Proteinases, Proteases, Acetylleucylleucylmethional, 136632-32-1, Calcium-Sensitive, 0384, Tocris Bioscience
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