Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 401.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.49 mL||12.45 mL||24.9 mL|
|5 mM||0.5 mL||2.49 mL||4.98 mL|
|10 mM||0.25 mL||1.25 mL||2.49 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the products' biological activity.
Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961 PMID: 9169469
Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636
If you know of a relevant reference for N-Acetyl-L-leucyl-L-leucyl-L-methional, please let us know.
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Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, supplier, Cathepsin, L, B, inhibitors, inhibits, Proteinases, Proteases, Acetylleucylleucylmethional, Cathepsin, Calcium-Sensitive, Proteases, Cathepsin, Tocris Bioscience
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