MTPG

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Cat.No. 0855 - MTPG | C10H11N5O2 | CAS No. 169209-66-9
Description: Group II/group III mGlu antagonist. More selective for group II than group III
Chemical Name: (RS)-α-Methyl-4-tetrazolylphenylglycine
Datasheet
Citations
Literature

Biological Activity

Group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies.

Technical Data

M. Wt 233.23
Formula C10H11N5O2
Storage Store at RT
CAS Number 169209-66-9
PubChem ID 1212
InChI Key OZBFBAYESADVDX-UHFFFAOYSA-N
Smiles CC(N)(C(O)=O)C1=CC=C(C=C1)C1=NN=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 233.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.29 mL 21.44 mL 42.88 mL
5 mM 0.86 mL 4.29 mL 8.58 mL
10 mM 0.43 mL 2.14 mL 4.29 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Bedingfield et al (1996) Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 309 71 PMID: 8864696

Bushell et al (1996) Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 117 1457 PMID: 8730739

Jane et al (1995) New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 851 PMID: 8532166


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Keywords: MTPG, supplier, Group, II, group, III, mGlur, antagonists, selective, Receptors, mGlu2, mGlu3, mGluR3, mGluR2, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience

Citations for MTPG

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Pathways for MTPG

Protocols

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