Molnupiravir

Pricing Availability   Qty
Cat.No. 7586 - Molnupiravir | C13H19N3O7 | CAS No. 2492423-29-5
Description: Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection
Chemical Name: β-D-N4-hydroxycytidine-5'-isopropyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Molnupiravir

Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). Molnupiravir competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, Molnupiravir improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.

Technical Data for Molnupiravir

M. Wt 329.31
Formula C13H19N3O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2492423-29-5
PubChem ID 145996610
InChI Key HTNPEHXGEKVIHG-QCNRFFRDSA-N
Smiles CC(C(OC[C@H]1O[C@@H](N2C=CC(NO)=NC2=O)[C@@H]([C@@H]1O)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Molnupiravir

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.93 100
water 32.93 100

Preparing Stock Solutions for Molnupiravir

The following data is based on the product molecular weight 329.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.18 mL 30.37 mL
5 mM 0.61 mL 3.04 mL 6.07 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Molnupiravir

References are publications that support the biological activity of the product.

Toots et al (2019) Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci.Transl.Med. 11 eaax5866 PMID: 31645453

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 eabb5883 PMID: 32253226

Gordon et al (2021) Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. J.Biol.Chem. 297 100770 PMID: 33989635


If you know of a relevant reference for Molnupiravir, please let us know.

Keywords: Molnupiravir, Molnupiravir supplier, broad-spectrum, antiviral, prodrug, nucleoside, analogue, analog, SARS-CoV-2, SARS-CoV, MERS-CoV, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, Coronavirus, Polymerase, 7586, Tocris Bioscience

Citations for Molnupiravir

Citations are publications that use Tocris products.

Currently there are no citations for Molnupiravir. Do you know of a great paper that uses Molnupiravir from Tocris? Please let us know.

Reviews for Molnupiravir

There are currently no reviews for this product. Be the first to review Molnupiravir and earn rewards!

Have you used Molnupiravir?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells