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Description: Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection
Chemical Name: β-D-N4-hydroxycytidine-5'-isopropyl ester
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Molnupiravir

Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). Molnupiravir competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, Molnupiravir improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.

Technical Data for Molnupiravir

M. Wt 329.31
Formula C13H19N3O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2492423-29-5
PubChem ID 145996610
Smiles CC(C(OC[C@H]1O[C@@H](N2C=CC(NO)=NC2=O)[C@@H]([C@@H]1O)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Molnupiravir

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.93 100
water 32.93 100

Preparing Stock Solutions for Molnupiravir

The following data is based on the product molecular weight 329.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.18 mL 30.37 mL
5 mM 0.61 mL 3.04 mL 6.07 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References for Molnupiravir

References are publications that support the biological activity of the product.

Toots et al (2019) Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci.Transl.Med. 11 eaax5866 PMID: 31645453

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 eabb5883 PMID: 32253226

Gordon et al (2021) Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. J.Biol.Chem. 297 100770 PMID: 33989635

If you know of a relevant reference for Molnupiravir, please let us know.

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Citations for Molnupiravir

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Literature in this Area

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