MMPIP hydrochloride

Discontinued Product

MMPIP hydrochloride (Cat. No. 2963) has been withdrawn from sale for commercial reasons.
Description: Potent and selective negative allosteric modulator of mGlu7 receptors
Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Purity: ≥98% (HPLC)
Citations (4)
Literature (3)

Biological Activity for MMPIP hydrochloride

MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

Technical Data for MMPIP hydrochloride

M. Wt 369.8
Formula C19H15N3O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1215566-78-1
PubChem ID 52974245
Smiles O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MMPIP hydrochloride

Certificate of Analysis / Product Datasheet
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References for MMPIP hydrochloride

References are publications that support the biological activity of the product.

Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147 PMID: 17609420

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Keywords: MMPIP hydrochloride, MMPIP hydrochloride supplier, Potent, allosteric, mGlu7, mGluR7-selective, antagonists, Group, III, Receptors, Glutamate, Metabotropic, NAM, (Metabotropic), 2963, Tocris Bioscience

4 Citations for MMPIP hydrochloride

Citations are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:

Jantas et al (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology 141 223 PMID: 30170084

Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17 PMID: 25881041

Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741 PMID: 26655894

Palazzo et al (2013) Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol Pain 9 44 PMID: 24004843

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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