MMPIP hydrochloride

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Cat.No. 2963 - MMPIP hydrochloride | C19H15N3O3.HCl | CAS No. 479077-02-6
Description: Potent, allosteric mGlu7-selective antagonist
Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

Technical Data

M. Wt 369.8
Formula C19H15N3O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 479077-02-6
PubChem ID 52974245
InChI Key HXHQNERSIJXMTQ-UHFFFAOYSA-N
Smiles O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.7 10

Preparing Stock Solutions

The following data is based on the product molecular weight 369.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.52 mL 27.04 mL
5 mM 0.54 mL 2.7 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147 PMID: 17609420


If you know of a relevant reference for MMPIP hydrochloride, please let us know.

Keywords: Potent allosteric mGlu7 mGluR7-selective antagonists Group III Receptors Glutamate Metabotropic Glutamate (Metabotropic) Group III Receptors

2 Citations for MMPIP hydrochloride

Citations are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:

Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741 PMID: 26655894

Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17 PMID: 25881041


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Pathways for MMPIP hydrochloride

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