Pricing Availability   Qty
Cat.No. 4511 - MMF | C5H6O4 | CAS No. 2756-87-8
Description: Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
Alternative Names: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for MMF

MMF is a nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).

Technical Data for MMF

M. Wt 130.1
Formula C5H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2756-87-8
PubChem ID 5369209
Smiles O=C(/C=C/C(O)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MMF

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.01 100
ethanol 13.01 100

Preparing Stock Solutions for MMF

The following data is based on the product molecular weight 130.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.69 mL 38.43 mL 76.86 mL
5 mM 1.54 mL 7.69 mL 15.37 mL
10 mM 0.77 mL 3.84 mL 7.69 mL
50 mM 0.15 mL 0.77 mL 1.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for MMF

References are publications that support the biological activity of the product.

Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207 PMID: 9613834

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910 PMID: 20664170

Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562 PMID: 18722346

Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544 PMID: 27580029

If you know of a relevant reference for MMF, please let us know.

Keywords: MMF, MMF supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF, mono-Methyl, fumarate, Antioxidants, Hydroxycarboxylic, Acid, Receptors, 4511, Tocris Bioscience

1 Citation for MMF

Citations are publications that use Tocris products. Selected citations for MMF include:

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep.

Do you know of a great paper that uses MMF from Tocris? Please let us know.

Reviews for MMF

There are currently no reviews for this product. Be the first to review MMF and earn rewards!

Have you used MMF?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review