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Cat.No. 4511 - MMF | C5H6O4 | CAS No. 2756-87-8
Description: Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
Alternative Names: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Purity: ≥99% (HPLC)

Biological Activity

Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).

Technical Data

M. Wt 130.1
Formula C5H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2756-87-8
PubChem ID 5369209
Smiles O=C(/C=C/C(O)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.01 100
ethanol 13.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 130.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.69 mL 38.43 mL 76.86 mL
5 mM 1.54 mL 7.69 mL 15.37 mL
10 mM 0.77 mL 3.84 mL 7.69 mL
50 mM 0.15 mL 0.77 mL 1.54 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207 PMID: 9613834

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910 PMID: 20664170

Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562 PMID: 18722346

Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544 PMID: 27580029

If you know of a relevant reference for MMF, please let us know.

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Citations for MMF

Citations are publications that use Tocris products.

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
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  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for MMF


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