Discontinued Product

MMF (Cat. No. 4511) has been withdrawn from sale for commercial reasons.
Description: Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
Alternative Names: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for MMF

MMF is a nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).

Technical Data for MMF

M. Wt 130.1
Formula C5H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2756-87-8
PubChem ID 5369209
Smiles O=C(/C=C/C(O)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for MMF

References are publications that support the biological activity of the product.

Rao & Mishra (1998) Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 60 207 PMID: 9613834

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Hanson et al (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 120 2910 PMID: 20664170

Tang et al (2008) The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 375 562 PMID: 18722346

Sciacovelli et al (2016) Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 537 544 PMID: 27580029

Keywords: MMF, MMF supplier, monomethylfumarate, nuclear, factor, erythroid, derived, like, 2, pathway, Nrf2, activators, GPR109A, niacin, nicotinic, acid, receptors, agonists, metabolite, dimethylfumarate, DMF, mono-Methyl, fumarate, Antioxidants, Hydroxycarboxylic, Acid, Receptors, 4511, Tocris Bioscience

1 Citation for MMF

Citations are publications that use Tocris products. Selected citations for MMF include:

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep.

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