DMF
Biological Activity
Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.
Technical Data
| M. Wt | 144.13 |
| Formula | C6H8O4 |
| Storage | Store at RT |
| Purity | ≥99% |
| CAS Number | 624-49-7 |
| PubChem ID | 637568 |
| InChI Key | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| Smiles | O=C(/C=C/C(OC)=O)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.41 | 100 | |
| ethanol | 7.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 144.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.94 mL | 34.69 mL | 69.38 mL |
| 5 mM | 1.39 mL | 6.94 mL | 13.88 mL |
| 10 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 50 mM | 0.14 mL | 0.69 mL | 1.39 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202
Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971
If you know of a relevant reference for DMF, please let us know.
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Keywords: DMF, supplier, dimethyl, fumarate, dimethylfumarate, nuclear, factor, erythroid, derived, like, 2, Nrf2, pathway, activators, antioxidants, cytoprotective, neuroprotective, experimental, autoimmune, encephalomyelitis, EAE, myelin, Dimethyl, fumarate, Antioxidants, Tocris Bioscience
Citations for DMF
Citations are publications that use Tocris products.
Currently there are no citations for DMF. Do you know of a great paper that uses DMF from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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