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Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%
Biological Activity
Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.
Technical Data
| M. Wt | 144.13 |
| Formula | C6H8O4 |
| Storage | Store at RT |
| Purity | ≥99% |
| CAS Number | 624-49-7 |
| PubChem ID | 637568 |
| InChI Key | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| Smiles | O=C(/C=C/C(OC)=O)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.41 | 100 | |
| ethanol | 7.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 144.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.94 mL | 34.69 mL | 69.38 mL |
| 5 mM | 1.39 mL | 6.94 mL | 13.88 mL |
| 10 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 50 mM | 0.14 mL | 0.69 mL | 1.39 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202
Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971
If you know of a relevant reference for DMF, please let us know.
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Keywords: DMF, DMF supplier, dimethyl, fumarate, dimethylfumarate, nuclear, factor, erythroid, derived, like, 2, Nrf2, pathway, activators, antioxidants, cytoprotective, neuroprotective, experimental, autoimmune, encephalomyelitis, EAE, myelin, Dimethyl, Antioxidants, 4512, Tocris Bioscience
Citations for DMF
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Reviews for DMF
Average Rating: 5 (Based on 1 Review.)
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Activation of nrf2 in mouse macrophages.
By
Anonymous on 09/24/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophage
used at 10um in mouse macrophages to activate NRF2
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