Home / Pharmacology / Other Pharmacology / Antioxidants / DMF

DMF

Cat. No. 4512 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 4512 - DMF | C6H8O4 | CAS No. 624-49-7
Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%
Datasheet
Citations
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data

M. Wt 144.13
Formula C6H8O4
Storage Store at RT
Purity ≥99%
CAS Number 624-49-7
PubChem ID 637568
InChI Key LDCRTTXIJACKKU-ONEGZZNKSA-N
Smiles O=C(/C=C/C(OC)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.41 100
ethanol 7.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 144.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.94 mL 34.69 mL 69.38 mL
5 mM 1.39 mL 6.94 mL 13.88 mL
10 mM 0.69 mL 3.47 mL 6.94 mL
50 mM 0.14 mL 0.69 mL 1.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971

If you know of a relevant reference for DMF, please let us know.

View Related Products by Target

Keywords: DMF, DMF supplier, dimethyl, fumarate, dimethylfumarate, nuclear, factor, erythroid, derived, like, 2, Nrf2, pathway, activators, antioxidants, cytoprotective, neuroprotective, experimental, autoimmune, encephalomyelitis, EAE, myelin, Dimethyl, Antioxidants, 4512, Tocris Bioscience

Citations for DMF

Citations are publications that use Tocris products.

Currently there are no citations for DMF. Do you know of a great paper that uses DMF from Tocris? Please let us know.

Reviews for DMF

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used DMF?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Activation of nrf2 in mouse macrophages.
By Anonymous on 09/24/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophage

used at 10um in mouse macrophages to activate NRF2

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells