Discontinued Product

DMF (Cat. No. 4512) has been withdrawn from sale for commercial reasons.
Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%

Biological Activity for DMF

DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data for DMF

M. Wt 144.13
Formula C6H8O4
Storage Store at RT
Purity ≥99%
CAS Number 624-49-7
PubChem ID 637568
Smiles O=C(/C=C/C(OC)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DMF

References are publications that support the biological activity of the product.

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971

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Citations for DMF

Citations are publications that use Tocris products.

Currently there are no citations for DMF.

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