DMF

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Cat.No. 4512 - DMF | C6H8O4 | CAS No. 624-49-7
Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%
Datasheet
Citations
Reviews
Literature

Biological Activity

Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data

M. Wt 144.13
Formula C6H8O4
Storage Store at RT
Purity ≥99%
CAS Number 624-49-7
PubChem ID 637568
InChI Key LDCRTTXIJACKKU-ONEGZZNKSA-N
Smiles O=C(/C=C/C(OC)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.41 100
ethanol 7.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 144.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.94 mL 34.69 mL 69.38 mL
5 mM 1.39 mL 6.94 mL 13.88 mL
10 mM 0.69 mL 3.47 mL 6.94 mL
50 mM 0.14 mL 0.69 mL 1.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971


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Citations for DMF

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Literature in this Area

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