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Cat.No. 4512 - DMF | C6H8O4 | CAS No. 624-49-7
Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%
Reviews (1)

Biological Activity for DMF

DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data for DMF

M. Wt 144.13
Formula C6H8O4
Storage Store at RT
Purity ≥99%
CAS Number 624-49-7
PubChem ID 637568
Smiles O=C(/C=C/C(OC)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMF

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.41 100
ethanol 7.21 50

Preparing Stock Solutions for DMF

The following data is based on the product molecular weight 144.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.94 mL 34.69 mL 69.38 mL
5 mM 1.39 mL 6.94 mL 13.88 mL
10 mM 0.69 mL 3.47 mL 6.94 mL
50 mM 0.14 mL 0.69 mL 1.39 mL

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References for DMF

References are publications that support the biological activity of the product.

Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202

Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971

If you know of a relevant reference for DMF, please let us know.

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Keywords: DMF, DMF supplier, dimethyl, fumarate, dimethylfumarate, nuclear, factor, erythroid, derived, like, 2, Nrf2, pathway, activators, antioxidants, cytoprotective, neuroprotective, experimental, autoimmune, encephalomyelitis, EAE, myelin, Dimethyl, Antioxidants, 4512, Tocris Bioscience

Citations for DMF

Citations are publications that use Tocris products.

Currently there are no citations for DMF. Do you know of a great paper that uses DMF from Tocris? Please let us know.

Reviews for DMF

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Activation of nrf2 in mouse macrophages.
By Anonymous on 09/24/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophage

used at 10um in mouse macrophages to activate NRF2