ML 786 dihydrochloride

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Cat.No. 5036 - ML 786 dihydrochloride | C29H29F3N4O3.2HCl | CAS No. 1237536-18-3
Description: Potent Raf kinase inhibitor; orally bioavailable
Alternative Names: BGB659
Chemical Name: 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). Also inhibits Abl-1, DDR2, EPHA2 and RET tyrosine kinase activity. Inhibits pERK formation and attenuates tumor growth in melanoma cell xenografts expressing the B-RafV600E mutation in vivo. Orally bioavailable.

Compound Libraries

ML 786 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 611.48
Formula C29H29F3N4O3.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1237536-18-3
PubChem ID 90488999
Smiles O=C(N[C@@H]2CCC(C=CC(OC4=C(CC5)C(NC=C4)=NC5=O)=C3)=C3C2)C1=CC(C(F)(F)F)=CC(C(N)(C)C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 61.15 100
DMSO 61.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 611.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.18 mL 16.35 mL
5 mM 0.33 mL 1.64 mL 3.27 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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References are publications that support the biological activity of the product.

Gould et al (2011) Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. J.Med.Chem. 54 1836 PMID: 21341678

Sase et al (2018) Acquired JHDM1D-BRAF fusion confers resistance to FGFR inhibition in FGFR2-amplified gastric cancer. Mol.Cancer Ther. 17 2217 PMID: 30045926

If you know of a relevant reference for ML 786 dihydrochloride, please let us know.

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1 Citation for ML 786 dihydrochloride

Citations are publications that use Tocris products. Selected citations for ML 786 dihydrochloride include:

Sase et al (2018) Acquired JHDM1D-BRAF fusion confers resistance to FGFR inhibition in FGFR2- amplified gastric cancer. Mol.Cancer Ther. PMID: 30045926

Do you know of a great paper that uses ML 786 dihydrochloride from Tocris? Please let us know.

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