ML 786 dihydrochloride
Potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). Also inhibits Abl-1, DDR2, EPHA2 and RET tyrosine kinase activity. Inhibits pERK formation and attenuates tumor growth in melanoma cell xenografts expressing the B-RafV600E mutation in vivo. Orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 611.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.64 mL||8.18 mL||16.35 mL|
|5 mM||0.33 mL||1.64 mL||3.27 mL|
|10 mM||0.16 mL||0.82 mL||1.64 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gould et al (2011) Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. J.Med.Chem. 54 1836 PMID: 21341678
If you know of a relevant reference for ML 786 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: ML 786 dihydrochloride, supplier, ML786, dihydrochloride, potent, raf, kinase, inhibitors, inhibits, b-raf, c-raf, V600E, mutation, tyrosine, kinases, Raf, Kinase, Raf, Kinase, Tocris Bioscience
Citations for ML 786 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for ML 786 dihydrochloride. Do you know of a great paper that uses ML 786 dihydrochloride from Tocris? If so please let us know.