Pentylenetetrazole

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Cat.No. 2687 - Pentylenetetrazole | C6H10N4 | CAS No. 54-95-5
Description: CNS stimulant
Alternative Names: PTZ
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data

M. Wt 138.17
Formula C6H10N4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 54-95-5
PubChem ID 5917
InChI Key CWRVKFFCRWGWCS-UHFFFAOYSA-N
Smiles C1CCN2N=NN=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.81 100
DMSO 13.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 138.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.24 mL 36.19 mL 72.37 mL
5 mM 1.45 mL 7.24 mL 14.47 mL
10 mM 0.72 mL 3.62 mL 7.24 mL
50 mM 0.14 mL 0.72 mL 1.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692

Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561

Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478


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Keywords: Pentylenetetrazole, Pentylenetetrazole supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, PTZ, Miscellaneous, GABA, 2687, Tocris Bioscience

1 Citation for Pentylenetetrazole

Citations are publications that use Tocris products. Selected citations for Pentylenetetrazole include:

Karim et al (2012) 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol 165 880 PMID: 21797842


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.