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Cat.No. 2687 - Pentylenetetrazole | C6H10N4 | CAS No. 54-95-5
Description: CNS stimulant
Alternative Names: PTZ
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity: ≥99% (HPLC)

Biological Activity

CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data

M. Wt 138.17
Formula C6H10N4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 54-95-5
PubChem ID 5917
Smiles C1CCN2N=NN=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.81 100
water 13.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 138.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.24 mL 36.19 mL 72.37 mL
5 mM 1.45 mL 7.24 mL 14.47 mL
10 mM 0.72 mL 3.62 mL 7.24 mL
50 mM 0.14 mL 0.72 mL 1.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692

Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561

Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478 PMID:

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.