CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 138.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.24 mL||36.19 mL||72.37 mL|
|5 mM||1.45 mL||7.24 mL||14.47 mL|
|10 mM||0.72 mL||3.62 mL||7.24 mL|
|50 mM||0.14 mL||0.72 mL||1.45 mL|
References are publications that support the products' biological activity.
Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692
Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561
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Keywords: Pentylenetetrazole, supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, PTZ, Miscellaneous, GABA, Miscellaneous, Glutamate, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience
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Literature in this Area
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.