ML 239

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Cat.No. 4829 - ML 239 | C13H10Cl3N3O2 | CAS No. 1378872-36-6
Description: Breast cancer stem cell inhibitor
Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.

Technical Data

M. Wt 346.6
Formula C13H10Cl3N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1378872-36-6
PubChem ID 90488975
InChI Key WOCCOXNODBCCGK-UHFFFAOYSA-N
Smiles ClC1=C(OCC(N/N=C/C2=CC=CN2)=O)C(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.66 100
ethanol 17.33 50

Preparing Stock Solutions

The following data is based on the product molecular weight 346.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.85 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204 PMID: 22941295

Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571 PMID: 22503247


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Keywords: ML 239, supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Cancer, Stem, Cells, Cancer, Stem, Cells, Tocris Bioscience

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Stem Cells Scientific Review

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