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Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 346.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.89 mL||14.43 mL||28.85 mL|
|5 mM||0.58 mL||2.89 mL||5.77 mL|
|10 mM||0.29 mL||1.44 mL||2.89 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204 PMID: 22941295
Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571 PMID: 22503247
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Keywords: ML 239, ML 239 supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Cancer, Stem, Cells, 4829, Tocris Bioscience
Citations for ML 239
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Reviews for ML 239
Average Rating: 5 (Based on 1 Review.)
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ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.
Dissolved in DMSO
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.