ML 130

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Cat.No. 4354 - ML 130 | C14H13N3O2S | CAS No. 799264-47-4
Description: Inhibits NOD1-induced NF-κB activation
Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.

Compound Libraries

ML 130 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 287.34
Formula C14H13N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 799264-47-4
PubChem ID 1088438
InChI Key SRFABRWQVPCPRG-UHFFFAOYSA-N
Smiles NC2=NC1=CC=CC=C1N2S(=O)(C3=CC=C(C)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.73 100
ethanol 2.87 10

Preparing Stock Solutions

The following data is based on the product molecular weight 287.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825 PMID: 21802003

Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780 PMID: 22003428


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View all NF-κB and IκB Inhibitors

Keywords: ML 130, supplier, ML130, nf-kb, nf-kappab, nf-μb, inhibitors, inhibits, NOD1, nucleotide-binding, oligomerization, domain, 1, selective, potent, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience

Citations for ML 130

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Literature in this Area

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Pathways for ML 130

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.