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Potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 287.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.48 mL||17.4 mL||34.8 mL|
|5 mM||0.7 mL||3.48 mL||6.96 mL|
|10 mM||0.35 mL||1.74 mL||3.48 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the biological activity of the product.
Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825 PMID: 21802003
Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780 PMID: 22003428
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Keywords: ML 130, ML 130 supplier, ML130, nf-kb, nf-kappab, nf-μb, inhibitors, inhibits, NOD1, nucleotide-binding, oligomerization, domain, 1, selective, potent, NF-kB/IkB, 4354, Tocris Bioscience
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