Home / Cell Biology / Signal Transduction / Cytokine and NF-κB Signaling / NF-κB and IκB / NF-κB and IκB Inhibitors / ML 130

ML 130

Cat. No. 4354 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Inhibits NOD1-induced NF-κB activation
Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 130

ML 130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.

Compound Libraries for ML 130

ML 130 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 130

M. Wt 287.34
Formula C14H13N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 799264-47-4
PubChem ID 1088438
InChI Key SRFABRWQVPCPRG-UHFFFAOYSA-N
Smiles NC2=NC1=CC=CC=C1N2S(=O)(C3=CC=C(C)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 130

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.73 100
ethanol 2.87 10

Preparing Stock Solutions for ML 130

The following data is based on the product molecular weight 287.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ML 130

References are publications that support the biological activity of the product.

Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825 PMID: 21802003

Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780 PMID: 22003428

If you know of a relevant reference for ML 130, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: ML 130, ML 130 supplier, ML130, nf-kb, nf-kappab, nf-μb, inhibitors, inhibits, NOD1, nucleotide-binding, oligomerization, domain, 1, selective, potent, NF-kB/IkB, 4354, Tocris Bioscience

Citations for ML 130

Citations are publications that use Tocris products.

Currently there are no citations for ML 130. Do you know of a great paper that uses ML 130 from Tocris? Please let us know.

Reviews for ML 130

There are currently no reviews for this product. Be the first to review ML 130 and earn rewards!

Have you used ML 130?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for ML 130

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.