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Cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 182.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.47 mL||27.37 mL||54.75 mL|
|5 mM||1.09 mL||5.47 mL||10.95 mL|
|10 mM||0.55 mL||2.74 mL||5.47 mL|
|50 mM||0.11 mL||0.55 mL||1.09 mL|
References are publications that support the biological activity of the product.
Yan et al (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol.Pharmacol. 47 248 PMID: 7870032
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Keywords: Carbamoylcholine chloride, Carbamoylcholine chloride supplier, Cholinergic, receptor, agonists, Muscarinic, Receptors, Acetylcholine, Nicotinic, Non-Selective, Subtypes, nAChR, Carbachol, Non-selective, Muscarinics, (Non-selective), 2810, Tocris Bioscience
11 Citations for Carbamoylcholine chloride
Citations are publications that use Tocris products. Selected citations for Carbamoylcholine chloride include:
Tozzi (2018) DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9 204 PMID: 29434188
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Ebner et al (2019) Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light. Front Synaptic Neurosci 11 16 PMID: 31178713
Jovancevic et al (2017) Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor. Basic Res Cardiol 112 13 PMID: 28116519
Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079
Goswami et al (2015) Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. PLoS One 10 e0131554 PMID: 26115342
Svalø et al (2015) Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction. Front Cell Neurosci 10 e0117350 PMID: 25692982
Martin et al (2015) Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Stem Cell Reports 9 457 PMID: 26648844
Hwangpo et al (2012) G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. J Biol Chem 287 13674 PMID: 22383529
Herrera-Rincon et al (2017) The brain is required for normal muscle and nerve patterning during early Xenopus development. Nat Commun 8 587 PMID: 28943634
Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101
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HEK293 cells were loaded with 1 µM cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM carbachol (CCh) in nominally Ca2+ free tyrode solution, resulting in transient cytosolic Ca2+ peak.
Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.