Carbamoylcholine chloride

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Description: Non-selective cholinergic agonist
Alternative Names: Carbachol
Chemical Name: (2-Hydroxyethyl)trimethylammonium chloride carbamate
Citations (11)
Reviews (1)
Literature (1)

Biological Activity for Carbamoylcholine chloride

Carbamoylcholine chloride is a cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.

Technical Data for Carbamoylcholine chloride

M. Wt 182.65
Formula C6H15ClN2O2
Storage Desiccate at RT
CAS Number 51-83-2
PubChem ID 5831
Smiles NC(OCC[N+](C)(C)C)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Carbamoylcholine chloride

Solvent Max Conc. mg/mL Max Conc. mM
water 18.27 100
DMSO 9.13 50

Preparing Stock Solutions for Carbamoylcholine chloride

The following data is based on the product molecular weight 182.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.47 mL 27.37 mL 54.75 mL
5 mM 1.09 mL 5.47 mL 10.95 mL
10 mM 0.55 mL 2.74 mL 5.47 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

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Product Datasheets for Carbamoylcholine chloride

Certificate of Analysis / Product Datasheet
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References for Carbamoylcholine chloride

References are publications that support the biological activity of the product.

Yan et al (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol.Pharmacol. 47 248 PMID: 7870032

If you know of a relevant reference for Carbamoylcholine chloride, please let us know.

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Keywords: Carbamoylcholine chloride, Carbamoylcholine chloride supplier, Cholinergic, receptor, agonists, Muscarinic, Receptors, Acetylcholine, Nicotinic, Non-Selective, Subtypes, nAChR, Carbachol, Non-selective, Muscarinics, (Non-selective), 2810, Tocris Bioscience

11 Citations for Carbamoylcholine chloride

Citations are publications that use Tocris products. Selected citations for Carbamoylcholine chloride include:

Tozzi (2018) DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9 204 PMID: 29434188

Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079

Ebner et al (2019) Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light. Front Synaptic Neurosci 11 16 PMID: 31178713

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114

Do you know of a great paper that uses Carbamoylcholine chloride from Tocris? Please let us know.

Reviews for Carbamoylcholine chloride

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Carbachol releases Ca2+ from ER stores in HEK293 cells..
By Anonymous on 12/15/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293

HEK293 cells were loaded with 1 µM cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM carbachol (CCh) in nominally Ca2+ free tyrode solution, resulting in transient cytosolic Ca2+ peak.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.