Carbamoylcholine chloride

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Cat.No. 2810 - Carbamoylcholine chloride | C6H15ClN2O2 | CAS No. 51-83-2
Description: Non-selective cholinergic agonist
Alternative Names: Carbachol
Chemical Name: (2-Hydroxyethyl)trimethylammonium chloride carbamate
Datasheet
Citations (8)
Reviews
Literature

Biological Activity

Cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.

Technical Data

M. Wt 182.65
Formula C6H15ClN2O2
Storage Desiccate at RT
CAS Number 51-83-2
PubChem ID 5831
InChI Key AIXAANGOTKPUOY-UHFFFAOYSA-N
Smiles NC(OCC[N+](C)(C)C)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.27 100
DMSO 9.13 50

Preparing Stock Solutions

The following data is based on the product molecular weight 182.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.47 mL 27.37 mL 54.75 mL
5 mM 1.09 mL 5.47 mL 10.95 mL
10 mM 0.55 mL 2.74 mL 5.47 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yan et al (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol.Pharmacol. 47 248 PMID: 7870032


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Keywords: Carbamoylcholine chloride, Carbamoylcholine chloride supplier, Cholinergic, receptor, agonists, Muscarinic, Receptors, Acetylcholine, Nicotinic, Non-Selective, Subtypes, nAChR, Carbachol, Non-selective, Muscarinics, (Non-selective), 2810, Tocris Bioscience

8 Citations for Carbamoylcholine chloride

Citations are publications that use Tocris products. Selected citations for Carbamoylcholine chloride include:

Tozzi (2018) Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9 204 PMID: 29434188

Jovancevic et al (2017) Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor. Basic Res Cardiol 112 13 PMID: 28116519

Goswami et al (2015) Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. PLoS One 10 e0131554 PMID: 26115342

Svalø et al (2015) Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction. Front Cell Neurosci 10 e0117350 PMID: 25692982

Martin et al (2015) Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Stem Cell Reports 9 457 PMID: 26648844

Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079

Hwangpo et al (2012) G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. J Biol Chem 287 13674 PMID: 22383529

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114


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Literature in this Area

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