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Submit ReviewMidazolam hydrochloride is a sedative/hypnotic agent that acts at the GABAA receptor benzodiazepine modulatory site.
M. Wt | 362.23 |
Formula | C18H13ClFN3.HCl |
Storage | Desiccate at RT |
Purity | ≥99% (HPLC) |
CAS Number | 59467-96-8 |
PubChem ID | 43032 |
InChI Key | PLYSCVSCYOQVRP-UHFFFAOYSA-N |
Smiles | FC(C=CC=C4)=C4C3=NCC1=CN=C(C)N1C2=CC=C(Cl)C=C23.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 9.06 | 25 |
The following data is based on the product molecular weight 362.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.25 mM | 11.04 mL | 55.21 mL | 110.43 mL |
1.25 mM | 2.21 mL | 11.04 mL | 22.09 mL |
2.5 mM | 1.1 mL | 5.52 mL | 11.04 mL |
12.5 mM | 0.22 mL | 1.1 mL | 2.21 mL |
References are publications that support the biological activity of the product.
Kanto (1985) Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy 5 138 PMID: 3161005
Olkkola and Ahonen (2008) Midazolam and other benzodiazepines. Handb.Exp.Pharmacol. 182 335 PMID: 18175099
If you know of a relevant reference for Midazolam hydrochloride, please let us know.
Keywords: Midazolam hydrochloride, Midazolam hydrochloride supplier, Benzodiazepine, agonists, GABAA, Receptors, Ro213981001, Dormicum, Ro, 21-3981/001, 2832, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Midazolam hydrochloride. Do you know of a great paper that uses Midazolam hydrochloride from Tocris? Please let us know.
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Midazolam was used to test a response of GABA-A receptors in cerebellar granule cells; the compound has shown a clear potentiatory effect. Figure: evoked EPSCs under control (black) and with 10 microM of Midazolam in perfusion solution (white).
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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