Midazolam hydrochloride

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Description: Benzodiazepine agonist
Alternative Names: Dormicum,Ro 21-3981/001
Chemical Name: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)

Biological Activity for Midazolam hydrochloride

Midazolam hydrochloride is a sedative/hypnotic agent that acts at the GABAA receptor benzodiazepine modulatory site.

Technical Data for Midazolam hydrochloride

M. Wt 362.23
Formula C18H13ClFN3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 59467-96-8
PubChem ID 43032
InChI Key PLYSCVSCYOQVRP-UHFFFAOYSA-N
Smiles FC(C=CC=C4)=C4C3=NCC1=CN=C(C)N1C2=CC=C(Cl)C=C23.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Midazolam hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.06 25

Preparing Stock Solutions for Midazolam hydrochloride

The following data is based on the product molecular weight 362.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.04 mL 55.21 mL 110.43 mL
1.25 mM 2.21 mL 11.04 mL 22.09 mL
2.5 mM 1.1 mL 5.52 mL 11.04 mL
12.5 mM 0.22 mL 1.1 mL 2.21 mL

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Product Datasheets for Midazolam hydrochloride

Certificate of Analysis / Product Datasheet
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References for Midazolam hydrochloride

References are publications that support the biological activity of the product.

Kanto (1985) Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy 5 138 PMID: 3161005

Olkkola and Ahonen (2008) Midazolam and other benzodiazepines. Handb.Exp.Pharmacol. 182 335 PMID: 18175099


If you know of a relevant reference for Midazolam hydrochloride, please let us know.

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Keywords: Midazolam hydrochloride, Midazolam hydrochloride supplier, Benzodiazepine, agonists, GABAA, Receptors, Ro213981001, Dormicum, Ro, 21-3981/001, 2832, Tocris Bioscience

Citations for Midazolam hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Midazolam hydrochloride. Do you know of a great paper that uses Midazolam hydrochloride from Tocris? Please let us know.

Reviews for Midazolam hydrochloride

Average Rating: 4 (Based on 1 Review.)

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Midazolam potentiates response of GABA-A receptors even in low concentration.
By Anonymous on 08/17/2019
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Cerebellum

Midazolam was used to test a response of GABA-A receptors in cerebellar granule cells; the compound has shown a clear potentiatory effect. Figure: evoked EPSCs under control (black) and with 10 microM of Midazolam in perfusion solution (white).

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.