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Biological Activity for Midazolam hydrochloride
Midazolam hydrochloride is a sedative/hypnotic agent that acts at the GABAA receptor benzodiazepine modulatory site.
Technical Data for Midazolam hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Midazolam hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Midazolam hydrochloride
The following data is based on the product molecular weight 362.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||11.04 mL||55.21 mL||110.43 mL|
|1.25 mM||2.21 mL||11.04 mL||22.09 mL|
|2.5 mM||1.1 mL||5.52 mL||11.04 mL|
|12.5 mM||0.22 mL||1.1 mL||2.21 mL|
Product Datasheets for Midazolam hydrochloride
References for Midazolam hydrochloride
References are publications that support the biological activity of the product.
Kanto (1985) Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy 5 138 PMID: 3161005
Olkkola and Ahonen (2008) Midazolam and other benzodiazepines. Handb.Exp.Pharmacol. 182 335 PMID: 18175099
If you know of a relevant reference for Midazolam hydrochloride, please let us know.
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Keywords: Midazolam hydrochloride, Midazolam hydrochloride supplier, Benzodiazepine, agonists, GABAA, Receptors, Ro213981001, Dormicum, Ro, 21-3981/001, 2832, Tocris Bioscience
Citations for Midazolam hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Midazolam hydrochloride. Do you know of a great paper that uses Midazolam hydrochloride from Tocris? Please let us know.
Reviews for Midazolam hydrochloride
Average Rating: 4.5 (Based on 2 Reviews.)
Have you used Midazolam hydrochloride?
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Midazolam was used to test a response of GABA-A receptors in cerebellar granule cells; the compound has shown a clear potentiatory effect. Figure: evoked EPSCs under control (black) and with 10 microM of Midazolam in perfusion solution (white).
It worked as planned, never had any issues.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.