Melperone hydrochloride

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Cat.No. 2495 - Melperone hydrochloride | C16H22FNO.HCl | CAS No. 1622-79-3
Description: 5-HT2A antagonist; also D2 antagonist; neuroleptic
Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (6)

Biological Activity for Melperone hydrochloride

Melperone hydrochloride is an atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).

Technical Data for Melperone hydrochloride

M. Wt 299.81
Formula C16H22FNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1622-79-3
PubChem ID 15386
Smiles Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Melperone hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 29.98 100
DMSO 29.98 100

Preparing Stock Solutions for Melperone hydrochloride

The following data is based on the product molecular weight 299.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.35 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets for Melperone hydrochloride

References for Melperone hydrochloride

References are publications that support the biological activity of the product.

Seeman et al (1997) Atypical neuroleptics have low affinity for DA D2 receptors or are selective for D4 receptors. Neuropsychopharmacology. 16 93 PMID: 9015795

Ichikawa et al (2002) Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase DA and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 956 349 PMID: 12445705

Uhr et al (2005) P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol. 18 509

If you know of a relevant reference for Melperone hydrochloride, please let us know.

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Keywords: Melperone hydrochloride, Melperone hydrochloride supplier, 5-HT2A/D2, receptor, antagonists, neuroleptic, Serotonin, Receptors, Dopamine, D2, dopaminergic, 5-HT2A, 2495, Tocris Bioscience

1 Citation for Melperone hydrochloride

Citations are publications that use Tocris products. Selected citations for Melperone hydrochloride include:

Hacker et al (2015) Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of MetF. with Experimental Substrates. Brain Res 10 e0136451 PMID: 26327616

Do you know of a great paper that uses Melperone hydrochloride from Tocris? Please let us know.

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Literature in this Area

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