Melperone hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2495 - Melperone hydrochloride | C16H22FNO.HCl | CAS No. 1622-79-3
Description: 5-HT2A/D2 receptor antagonist; neuroleptic
Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).

Compound Libraries

Melperone hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 299.81
Formula C16H22FNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1622-79-3
PubChem ID 15386
InChI Key MQHYXXIJLKFQGY-UHFFFAOYSA-N
Smiles Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.98 100
ethanol 29.98 100
water 29.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.35 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Seeman et al (1997) Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology. 16 93 PMID: 9015795

Ichikawa et al (2002) Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 956 349 PMID: 12445705

Uhr et al (2005) P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol. 18 509 PMID:


If you know of a relevant reference for Melperone hydrochloride, please let us know.

View Related Products by Product Action

View all 5-HT2A Receptor Antagonists

Keywords: Melperone hydrochloride, supplier, 5-HT2A/D2, receptor, antagonists, neuroleptic, Serotonin, Receptors, Dopamine, D2, dopaminergic, 5-HT2A, Receptors, Tocris Bioscience

1 Citation for Melperone hydrochloride

Citations are publications that use Tocris products. Selected citations for Melperone hydrochloride include:

Hacker et al (2015) Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates. Brain Res 10 e0136451 PMID: 26327616


Do you know of a great paper that uses Melperone hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Melperone hydrochloride

Protocols

TODO: Add Protocols