MEK Inhibitor Tocriset™

Discontinued Product

MEK Inhibitor Tocriset™ (Cat. No. 2243) has been withdrawn from sale for commercial reasons.

Contents of Tocriset:

Cat. No. Product Name / Activity
1969 SL 327
selective inhibitor of MEK1 and MEK2; brain penetrant
1144 U0126
potent, selective inhibitor of MEK1 and MEK2
1213 PD 98059
specific inhibitor of MAPKK/MEK
Description: Selection of 3 MEK inhibitors (Cat. Nos. 1213, 1969 and 1144)
Literature (1)
Pathways (1)

Biological Activity for MEK Inhibitor Tocriset™

Contains the listed products which can be used to selectively inhibit MEK signalling. The products are supplied either as a solid (U0126) or pre-dissolved in DMSO at a stock concentration of 10 mM in 0.5 ml.

Technical Data for MEK Inhibitor Tocriset™

Tocrisets contain 3-5 ligands supplied as lyophilized solids or pre-dissolved in DMSO at a specified concentration. Lyophilized solids have been freeze-dried (approximately 0.5-2 mg per vial) so that addition of 0.5 or 1 ml of solvent produces a stock concentration of 10 or 5 mM respectively.

Please see individual product listings for specific technical data and certificate of analysis.

Technical Data for MEK Inhibitor Tocriset™

Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MEK Inhibitor Tocriset™

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for MEK Inhibitor Tocriset™

References are publications that support the biological activity of the product.

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View all MEK Ligand Sets

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Citations for MEK Inhibitor Tocriset™

Citations are publications that use Tocris products.

Currently there are no citations for MEK Inhibitor Tocriset™.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for MEK Inhibitor Tocriset™

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.