MEK Inhibitor Tocriset™

Discontinued Product

MEK Inhibitor Tocriset™ (Cat. No. 2243) has been withdrawn from sale for commercial reasons.

Contents of Tocriset:

Cat. No. Product Name / Activity
1213 PD 98059
specific inhibitor of MAPKK/MEK
1144 U0126
potent, selective inhibitor of MEK1 and MEK2
1969 SL 327
selective inhibitor of MEK1 and MEK2; brain penetrant
Description: Selection of 3 MEK inhibitors (Cat. Nos. 1213, 1969 and 1144)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Contains the listed products which can be used to selectively inhibit MEK signalling. The products are supplied either as a solid (U0126) or pre-dissolved in DMSO at a stock concentration of 10 mM in 0.5 ml.

Technical Data

Tocrisets contain 3-5 ligands supplied as lyophilized solids or pre-dissolved in DMSO at a specified concentration. Lyophilized solids have been freeze-dried (approximately 0.5-2 mg per vial) so that addition of 0.5 or 1 ml of solvent produces a stock concentration of 10 or 5 mM respectively.

Please see individual product listings for specific technical data and certificate of analysis.

Technical Data

Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References

References are publications that support the biological activity of the product.

View Related Products by Product Action

View all MEK Ligand Sets

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Citations for MEK Inhibitor Tocriset™

Citations are publications that use Tocris products.

Currently there are no citations for MEK Inhibitor Tocriset™.

Reviews for MEK Inhibitor Tocriset™

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for MEK Inhibitor Tocriset™

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.